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United States 

Sulindac sulfide

COX inhibitor
BML-AP200-0005 5 mg 88.00 USD
BML-AP200-0025 25 mg 269.00 USD
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Replaces Prod. #: ALX-430-106

Active metabolite of sulindac (Prod. No. ALX-430-105). Inhibits cyclooxygenase. More selective for PGHS-1 (ID50=0.5 µM) over PGHS-2 (ID50=14 µM). Induces apoptosis by a cyclooxygenase-independent mechanism. Inhibits colorectal cancer growth and γ-secretase. NF-κB inhibitor. Inhibits Ras signaling.

Product Details

Alternative Name:Z-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic acid
Purity:≥99% (TLC)
Appearance:Yellow-orange solid.
Solubility:Soluble in DMSO (>25mg/ml) or 100% ethanol (5mg/ml, warm).
Shipping:Ambient Temperature
Long Term Storage:Ambient
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C.
Regulatory Status:RUO - Research Use Only
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Product Literature References

PKGI mediates the growth inhibitory effects of cGMP signaling in human breast cancer cells independent of β-catenin: P.F. Windham, et al.; Integr. Cancer Sci. Therap. 2, 185 (2015), Application(s): Western Blot, Full Text
Sulindac inhibits activation of the NF-kappaB pathway: Y. Yamamoto, et al.; J. Biol. Chem. 274, 27307 (1999), Abstract;
Sulindac sulfide inhibits Ras signaling: C. Herrmann, et al.; Oncogene 17, 1769 (1998), Abstract;
Antineoplastic drugs sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis: G.A. Piazza, et al.; Cancer Res. 55, 3110 (1995), Abstract;
Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs: E.A. Meade, et al.; J. Biol. Chem. 268, 6610 (1993), Abstract;