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Matrix Metalloproteinase-3 (MMP-3) fluorometric drug discovery kit

BML-AK401-0001 96 wells 536.00 USD
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A QUANTIZYME® Assay System. The MMP-3 Fluorometric (also known as fluorimetric) Drug Discovery Kit is a complete assay system designed to screen inhibitors of matrix metalloproteinase-3 (MMP-3, stromelysin-1) using a quenched fluorogenic peptide: OMNIMMP® fluorogenic substrate Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH. Mca fluorescence is quenched by the Dpa group until cleavage by MMPs at the Gly-Leu bond separates the two moieties. The assays are performed in a convenient 96-well microplate format. The kit is useful to screen inhibitors of MMP-3, a potential therapeutic target. Included are active enzyme, assay buffer, a prototypic control inhibitor (NNGH3), and a detailed instruction booklet.

Product Specification

Alternative Name:Stromelysin-1, Transin-1
Applications:Fluorescent detection, HTS
Activity assay
Shipping:Shipped on Dry Ice
Long Term Storage:-80°C
Contents:MMP-3 enzyme (human) (recombinant), substrate, calibration standard, inhibitor, assay buffer, 96-well white microplate.
UniProt ID:P08254

Product Literature References

Photocontrol of Peptide function: backbone cyclization strategy with photocleavable amino Acid: N. Umezawa, et al.; Chembiochem 12, 1694 (2011), Abstract;
Hippocampal MMP-3 elevation is associated with passive avoidance conditioning: M.L. Olson, et al.; Regul. Pep. 146, 19 (2008), Abstract;

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