The SCREEN-WELL® Phosphatase Inhibitor Library contains 33 known phosphatase inhibitors of well-defined activity. Inhibitors are supplied dissolved in DMSO at 10 mM and aliquoted into deep-well plates at either 100 µl or 500 µl per well. The library is ideal for chemical genomics, assay development, and as a reference set for secondary screening. Includes inhibitors of these important phosphatases: Calcineurin(PP2B), JSP-1, PRL-1, CD45, PP1, PRL-3, CDC25, PP2A, PTEN, and many more.
Product Details
| Applications: | HTS
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| Use/Stability: | Stable for at least one year from the date of receipt when stored at -80°C. |
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| Shipping: | Shipped on Dry Ice |
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| Long Term Storage: | -80°C |
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| Technical Info/Product Notes: |  |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Phosphatase inhibitors BVT-948 and alexidine dihydrochloride inhibit sexual development of the malaria parasite Plasmodium berghei: X. Jia, et al.; Int. J. Parasitol. Drugs Drug Resist.
19, 81 (2022),
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Discovery of uncompetitive inhibitors of SapM that compromise intracellular survival of Mycobacterium tuberculosis: P.F. Soto, et al.; Sci. Rep.
11, 7667 (2021),
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Image-based high-throughput mapping of TGF-β-induced phosphocomplexes at a single-cell level: P. Lönn, et al.; Commun. Biol.
4, 1284 (2021),
Abstract;
Eukaryotic phosphatase inhibitors enhance colistin efficacy in gram‐negative bacteria: W.T. Barker, et al.; Chem. Biol. Drug Des.
96, 1180 (2020),
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BML-265 and tyrphostin AG1478 disperse the Golgi apparatus and abolish protein transport in human cells: G. Boncompain, et al.; Front. Cell. Dev. Biol.
7, 232 (2019),
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Plasmodium berghei serine/threonine protein phosphatase PP5 plays a critical role in male gamete fertility: X. Zhu, et al.; Int. J. Parasitol.
49, 685 (2019),
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Therapeutic Chemical Screen Identifies Phosphatase Inhibitors to Reconstitute PKB Phosphorylation and Cardiac Contractility in ILK-Deficient Zebrafish: A. Pott, et al.; Biomolecules
8, 153 (2018),
Abstract;
Identification of antipsychotic drug fluspirilene as a potential anti-glioma stem cell drug: Y. Dong, et al.; Oncotarget
8, 111728 (2017),
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Macrolides selectively inhibit mutant KCNJ5 potassium channels that cause aldosterone-producing adenoma: U.I. Scholl, et al.; J. Clin. Invest.
127, 2739 (2017),
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Sorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury: S. Martens, et al.; Cell Death Dis.
8, e2904 (2017),
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Therapeutic strategy for targeting aggressive malignant gliomas by disrupting their energy balance: A.M. Hegazy, et al.; J. Biol. Chem.
291, 21496 (2016),
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PRL-3 mediates the protein maturation of ULBP2 by regulating the tyrosine phosphorylation of HSP60: W.H. Leung, et al.; J. Immunol.
194, 2930 (2015),
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An inverse small molecule screen to design a chemically defined medium supporting long-term growth of Drosophila cell lines: M. Burnette, et al.; Mol. Biosyst.
10, 2713 (2014),
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High-content screening identifies small molecules that remove nuclear foci, affect MBNL distribution and CELF1 protein levels via a PKC-independent pathway in myotonic dystrophy cell lines: A. Ketley, et al.; Hum. Mol. Genet.
23, 1551 (2014),
Application(s): Screening of fibroblasts,
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High throughput screening for small molecule enhancers of the interferon signaling pathway to drive next-generation antiviral drug discovery: D.A. Patel, et al.; PLoS One
7, e36594 (2012),
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Small molecule screening identifies targetable zebrafish pigmentation pathways: S. Colanesi, et al.; Pigment Cell Melanoma Res.
25, 131 (2012),
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A phenotypic small-molecule screen identifies an orphan ligand-receptor pair that regulates neural stem cell differentiation: J. P. Saxe; Chem. Biol.
14, 1019 (2007),
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