The SCREEN-WELL® Nuclear Receptor Ligand Library contains 74 compounds with defined, putative and potential activity at nuclear receptors. Receptor agonists and antagonists are included. The library consists of a chemically diverse group of compounds which are supplied dissolved in DMSO at 10 mM (1mM for 5 compounds) and aliquoted into deep-well, 96-well plates at 500 µl or 100 µl per well. The library is an ideal tool for chemical genomics, receptor de-orphaning and other routine pharmacological applications. The library includes ligands for the following classes of nuclear receptors: AHR, CAR, ER, FXR, LXR, PPAR, PXR, RAR, RXR, VDR, and other steroid receptors.
Product Details
| Applications: | HTS
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| Use/Stability: | Stable for at least one year from the date of receipt when stored at -80°C. |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -80°C |
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| Technical Info/Product Notes: | 
Application Note: High Throughput Screening Applications. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
ISX-9 potentiates CaMKIIδ-mediated BMAL1 activation to enhance circadian amplitude: H. Li, et al.; Commun. Biol.
5, 750 (2022),
Abstract;
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Nuclear receptor ligand screening in an iPSC-derived in vitro blood-brain barrier model identifies new contributors to leptin transport: Y. Shi, et al.; Fluids Barriers CNS
19, 77 (2022),
Abstract;
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CD10 marks non-canonical PPARγ-independent adipocyte maturation and browning potential of adipose-derived stem cells: S. Chakraborty, et al.; Stem Cell Res. Ther.
12, 109 (2021),
Abstract;
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Complex interplay among nuclear receptor ligands, cytosine methylation, and the metabolome in driving tris (1, 3-dichloro-2-propyl) phosphate-induced epiboly defects in zebrafish: S. Dasgupta, et al.; Environ. Sci. Technol.
53, 10497 (2019),
Abstract;
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Fast Adipogenesis Tracking System (FATS) - a robust, high-throughput, automation-ready adipogenesis quantification technique: C. Yuan, et al.; Stem Cell Res. Ther.
10, 38 (2019),
Abstract;
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Antagonism of PPAR-γ signaling expands human hematopoietic stem and progenitor cells by enhancing glycolysis: B. Guo, et al.; Nat. Med.
24, 360 (2018),
Abstract;
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Disruption of nuclear receptor signaling alters triphenyl phosphate-induced cardiotoxicity in zebrafish embryos: C.A. Mitchell, et al.; Toxicol. Sci.
163, 307 (2018),
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Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency: Y. Yang, et al.; Cell
169, 243 (2017),
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Glucocorticoid hormone-induced chromatin remodeling enhances human hematopoietic stem cell homing and engraftment: B. Guo, et al.; Nat. Med.
23, 424 (2017),
Abstract;
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Live cell screening platform identifies PPARδ as a regulator of cardiomyocyte proliferation and cardiac repair: A. Magadum, et al.; Cell Res.
27, 1002 (2017),
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Macrolides selectively inhibit mutant KCNJ5 potassium channels that cause aldosterone-producing adenoma: U.I. Scholl, et al.; J. Clin. Invest.
127, 2739 (2017),
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Use of differential scanning fluorimetry to identify nuclear receptor ligands: K.A. DeSantis, et al.; Methods Mol. Biol.
1443, 21 (2016),
Abstract;
Whole organism high content screening identifies stimulators of pancreatic beta-cell proliferation: N. Tsuji, et al.; PLoS One
9, e104112 (2014),
Abstract;
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