Product Details
Alternative Name: | A-Proliferation-inducing ligand, TNFSF 13, CD256 |
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Clone: | Aprily-2 |
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Host: | Mouse |
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Isotype: | IgG1 |
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Immunogen: | Recombinant human APRIL (aa 93-233). |
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UniProt ID: | O75888 |
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Source: | Purified from concentrated hybridoma tissue culture supernatant. |
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Species reactivity: | Human
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Applications: | IHC (PS)
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Recommended Dilutions/Conditions: | Immunohistochemistry (paraffin sections (1:500)) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
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Application Notes: | Immunohistochemistry (paraffin sections, 1:500). Optimal conditions must be determined individually for each application. |
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Formulation: | Liquid. In PBS containing 0.02% sodium azide. |
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Use/Stability: | Stable for at least 1 year after receipt when stored as recommended. |
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Handling: | Avoid freeze/thaw cycles. |
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Shipping: | Shipped on Blue Ice |
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Short Term Storage: | +4°C |
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Long Term Storage: | -20°C |
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Regulatory Status: | RUO - Research Use Only |
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Figure: Biopsy of tumor lesion from a patient with lymphoma (DLBCL) stained with MAb to APRIL (Aprily-2) (
ALX-804-844). The biopsy was stained by standard immunohistochemistry. The figure shows the selective accumulation of APRIL around tumor cells.
Picture courtesy of Dr. Bertrand Huard (University of Geneva)."
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Product Literature References
Macrophage-mediated chronic lymphocytic leukemia cell survival is independent of APRIL signaling: M.H.A. van Attekum, et al.; Cell Death Discov.
2, 16020 (2016),
Application(s): IHC on PPFE,
Abstract;
Full Text
The source of APRIL up-regulation in human solid tumor lesions: P. Mhawech-Fauceglia, et al.; J. Leukoc. Biol.
80, 697 (2006),
Abstract;
General Literature References
BAFF and APRIL: A Tutorial on B Cell Survival: F. Mackay, et al.; Annu. Rev. Immunol. (2002),
Abstract;