Product Details
Alternative Name: | p88, IP90 |
|
Clone: | AF18 |
|
Host: | Mouse |
|
Isotype: | IgG1 |
|
Immunogen: | Focus human hepatoma cell line. |
|
UniProt ID: | P27824 |
|
Species reactivity: | Human, Mouse
|
|
Applications: | ICC, IP, WB
|
|
Recommended Dilutions/Conditions: | Immunocytochemistry (1:500) Immunoprecipitation, Western Blot (1:4,000) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
|
Application Notes: | Detects a band of ~90kDa by Western blot. |
|
Formulation: | Liquid. Ascites diluted in PBS containing 0.05% sodium azide. |
|
Handling: | Avoid freeze/thaw cycles. |
|
Shipping: | Blue Ice |
|
Long Term Storage: | -20°C |
|
Scientific Background: | Calnexin, also referred to as IP90 or p88, is a ~88kDa chaperone protein found in the endoplastmic reticulum. It binds with partially folded immunoglobulin proteins and retains them in the endoplastmic reticulum until they are completely folded. |
|
Regulatory Status: | RUO - Research Use Only |
|
Product Literature References
VAP (VAMP-Associated Proteins) as Receptors that couple Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Proteostasis with Lipid Homeostasis: W.L. Ernst, et al.; J. Biol. Chem.
291, 5206 (2016),
Application(s): Cell culture,
Abstract;
Full Text
Cysteine string protein monitors late steps in cystic fibrosis transmembrane conductance regulator biogenesis: H. Zhang, et al.; J. Biol. Chem.
281, 11312 (2006),
Abstract;
Full Text
The liver-enriched transcription factor CREB-H is a growth suppressor protein underexpressed in hepatocellular carcinoma: K.T. Chin, et al.; Nucl. Acids Res.
33, 1859 (2005),
Abstract;
Full Text
The stop transfer sequence of the human UDP-glucuronosyltransferase 1A determines localization to the endoplasmic reticulum by both static retention and retrieval mechanisms: L. Barre, et al.; Febs J.
272, 1063 (2005),
Abstract;
Full Text
An LQT mutant minK alters KvLQT1 trafficking: A. Krumerman, et al.; Am. J. Physiol. Cell Physiol.
286, C1453 (2004),
Abstract;
Transient calnexin interaction confers long-term stability on folded K+ channel protein in the ER: R. Khanna, et al.; J. Cell Sci.
117, 2897 (2004),
Abstract;
Full Text
Sec13 shuttles between the nucleus and the cytoplasm and stably interacts with Nup96 at the nuclear pore complex: J. Enninga, et al.; Mol. Cell. Biol.
23, 7271 (2003),
Abstract;
Full Text
c-erbB-3: a nuclear protein in mammary epithelial cells: M. Offterdinger, et al.; J. Cell Biol.
157, 929 (2002),
Abstract;
Full Text
Cysteine string protein interacts with and modulates the maturation of the cystic fibrosis transmembrane conductance regulator: H. Zhang, et al.; J. Biol. Chem.
277, 28948 (2002),
Abstract;
Full Text
FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction: B.N. Desai, et al.; PNAS
99, 4319 (2002),
Abstract;
Full Text
Formation of transitory intrachain and interchain disulfide bonds accompanies the folding and oligomerization of simian virus 40 Vp1 in the cytoplasm: P.P. Li, et al.; PNAS
99, 1353 (2002),
Abstract;
Full Text
The major histocompatibility complex class I antigen-binding protein p88 is the product of the calnexin gene: K. Galvin, et al.; PNAS
89, 8452 (1992),
Abstract;
Full Text