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Calnexin monoclonal antibody (AF18)

 
ALX-804-014-R100 100 µl 764.00 USD
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Product Details

Alternative Name:p88, IP90
 
Clone:AF18
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Focus human hepatoma cell line.
 
UniProt ID:P27824
 
Species reactivity:Human, Mouse
 
Applications:ICC, IP, WB
 
Recommended Dilutions/Conditions:Immunocytochemistry (1:500)
Immunoprecipitation, Western Blot (1:4,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~90kDa by Western blot.
 
Formulation:Liquid. Ascites diluted in PBS containing 0.05% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Calnexin, also referred to as IP90 or p88, is a ~88kDa chaperone protein found in the endoplastmic reticulum. It binds with partially folded immunoglobulin proteins and retains them in the endoplastmic reticulum until they are completely folded.
 
Regulatory Status:RUO - Research Use Only
 

Product Literature References

VAP (VAMP-Associated Proteins) as Receptors that couple Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Proteostasis with Lipid Homeostasis: W.L. Ernst, et al.; J. Biol. Chem. 291, 5206 (2016), Application(s): Cell culture, Abstract; Full Text
Cysteine string protein monitors late steps in cystic fibrosis transmembrane conductance regulator biogenesis: H. Zhang, et al.; J. Biol. Chem. 281, 11312 (2006), Abstract; Full Text
The liver-enriched transcription factor CREB-H is a growth suppressor protein underexpressed in hepatocellular carcinoma: K.T. Chin, et al.; Nucl. Acids Res. 33, 1859 (2005), Abstract; Full Text
The stop transfer sequence of the human UDP-glucuronosyltransferase 1A determines localization to the endoplasmic reticulum by both static retention and retrieval mechanisms: L. Barre, et al.; Febs J. 272, 1063 (2005), Abstract; Full Text
An LQT mutant minK alters KvLQT1 trafficking: A. Krumerman, et al.; Am. J. Physiol. Cell Physiol. 286, C1453 (2004), Abstract;
Transient calnexin interaction confers long-term stability on folded K+ channel protein in the ER: R. Khanna, et al.; J. Cell Sci. 117, 2897 (2004), Abstract; Full Text
Sec13 shuttles between the nucleus and the cytoplasm and stably interacts with Nup96 at the nuclear pore complex: J. Enninga, et al.; Mol. Cell. Biol. 23, 7271 (2003), Abstract; Full Text
c-erbB-3: a nuclear protein in mammary epithelial cells: M. Offterdinger, et al.; J. Cell Biol. 157, 929 (2002), Abstract; Full Text
Cysteine string protein interacts with and modulates the maturation of the cystic fibrosis transmembrane conductance regulator: H. Zhang, et al.; J. Biol. Chem. 277, 28948 (2002), Abstract; Full Text
FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction: B.N. Desai, et al.; PNAS 99, 4319 (2002), Abstract; Full Text
Formation of transitory intrachain and interchain disulfide bonds accompanies the folding and oligomerization of simian virus 40 Vp1 in the cytoplasm: P.P. Li, et al.; PNAS 99, 1353 (2002), Abstract; Full Text
The major histocompatibility complex class I antigen-binding protein p88 is the product of the calnexin gene: K. Galvin, et al.; PNAS 89, 8452 (1992), Abstract; Full Text

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