Replaces Prod. #: ALX-801-029
Product Details
| Alternative Name: | MXR, BCRP, ABCG2, CD338 |
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| Clone: | BXP-21 |
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| Host: | Mouse |
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| Isotype: | IgG2a |
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| Immunogen: | Recombinant human BCRP (breast cancer resistance protein; MXR) (aa 271-396). |
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| UniProt ID: | Q9UNQ0 |
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| Species reactivity: | Human
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| Specificity: | Recognizes an internal epitope of human BCRP. |
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| Crossreactivity: | Does not cross-react with human P-glycoprotein, MRP1 or MRP2. |
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| Applications: | ICC, IHC (FS), IHC (PS), WB
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| Recommended Dilutions/Conditions: | Immunocytochemistry: Use 1:20-1:50 dilution on acetone fixed cytospin preparations.
Immunohistochemistry (frozen sections): Use 1:20 dilution on acetone fixed frozen sections followed by incubation with rabbit anti-mouse IgG and a monoclonal mouse APAAP complex.
Immunohistochemistry (paraffin sections): Use on formaldehyde-fixed paraffin-embedded human tissues and tumors after pretreatment with 10mM citric acid, pH 6.0, for 20 min.
Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
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| Application Notes: | Immunocytochemistry: cytospin preparations |
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| Formulation: | Liquid. In PBS containing 0.1% BSA and 0.02% sodium azide. |
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| Shipping: | Shipped on Blue Ice |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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General Literature References
A multidrug resistance transporter from human MCF-7 breast cancer cells: L.A. Doyle, et al.; PNAS
95, 15665 (1998),
Abstract;
Full Text
