Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

MRP1 monoclonal antibody (MRPr1)

ALX-801-007-C125 125 µg 504.00 USD
ALX-801-007-C250 250 µg 951.00 USD
Do you need bulk/larger quantities?

Product Details

Alternative Name:Multidrug resistance-associated protein 1, ABCC1
Immunogen:Recombinant human MRP1 (multidrug resistance-associated protein 1) (aa 192-360).
UniProt ID:P33527
Species reactivity:Human, Mouse
Specificity:Recognizes the internal epitope (G238SDLWSLNKE247) of MRP1, overexpressed in various human non-P-glycoprotein MDR tumor cell lines.
Crossreactivity:Does not cross-react with human P-glycoprotein, MDR3 P-glycoprotein or human MRP2 (cMOAT) to MRP 5.
Applications:Flow Cytometry, ICC, IHC (FS), IHC (PS), WB
Recommended Dilutions/Conditions:Suggested starting dilution is 1:20
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Flow Cytometry: cell permeabilization required
Immunocytochemistry: cytospin preparations
Formulation:Liquid. In serum free culture supernatant containing 0.7% BSA and 0.1% sodium azide.
Shipping:Shipped on Blue Ice
Short Term Storage:+4°C
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only
MRP1 (human) monoclonal antibody (MRPm6) Epitope mapping
Figure: Epitope Mapping of MAbs MRPr1, QCRL-1 & MRPm6. Topological model of MRPdepicting the approx. locations of the MRPr1, QCRL-1 and MRPm6 epitopes. The model shown is only one of several possible configurations. MSD=membrane spanning domain; NBD=nucleotide binding domain. From R. Hipfner, et al.; Br. J. Cancer 78,1134 (1998).
Please mouse over
MRP1 (human) monoclonal antibody (MRPm6) Epitope mapping

Product Literature References

Localization of MRP-1 to the outer mitochondrial membrane by the chaperone protein HSP90β: E. Roundhill, et al.; FASEB J. 30, 1712 (2016), Abstract;
Characterization of efflux transport proteins of the human choroid plexus papilloma cell line HIBCPP, a functional in vitro model of the blood-cerebrospinal fluid barrier: A. Bernd, et al.; Pharm. Res. 32, 2973 (2015), Abstract;
Identification of new MRP4 inhibitors from a library of FDA approved drugs using a high-throughput bioluminescence screen: L. Cheung, et al.; Biochem. Pharmacol. 93, 380 (2015), Application(s): Western blot with HEK293 cells, Abstract;
Inhibition of Multidrug resistance protein 1 (MRP1) improves chemotherapy drug response in primary and recurrent glioblastoma multiforme: A. Tivnan, et al.; Front. Neurosci. 9, 218 (2015), Application(s): Western Blot, Abstract; Full Text
The effect of maternal obesity on the expression and functionality of placental P-glycoprotein: Implications in the individualized transplacental digoxin treatment for fetal heart failure: C. Wang, et al.; Placenta 36, 1138 (2015), Application(s): Western blot with human placenta, Abstract; Full Text
High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4): L. Cheung, et al.; Biochem. Pharmacol. 91, 97 (2014), Application(s): Western blot with MCF7 cells, Abstract;
Effect of multiple cysteine substitutions on the functionality of human multidrug resistance protein 1 expressed in human embryonic kidney 293 cells: identification of residues essential for function: L. Qin, et al.; Drug. Metab. Dispos. 40, 1403 (2012), Application(s): Immunofluorescence using HEK293 cells, Abstract;
Inflammatory regulation of ATP binding cassette efflux transporter expression and function in microglia: C.J. Gibson, et al.; J. Pharmacol. Exp. Ther. 343, 650 (2012), Application(s): Western blot with BV-2 cells, Abstract; Full Text
Identification and characterization of functionally important elements in the multidrug resistance protein 1 COOH-terminal region: C.J. Westlake, et al.; J. Biol. Chem. 279, 53571 (2004), Abstract; Full Text
Rhodamine 123 binds to multiple sites in the multidrug resistance protein (MRP1): R. Daoud, et al.; Biochemistry 39, 15344 (2000), Abstract;
Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies: G.L. Scheffer, et al.; Cancer Res. 60, 5269 (2000), Abstract; Full Text
The multidrug resistance protein 1: a functionally important activation marker for murine Th1 cells: S. Prechtl, et al.; J. Immunol. 164, 754 (2000), Abstract; Full Text
The multidrug resistance protein is photoaffinity labeled by a quinoline-based drug at multiple sites: R. Daoud, et al.; Biochemistry 39, 6094 (2000), Abstract;
Bcl-2, bax and bcl-xL expression in human sensitive and resistant leukemia cell lines: V. Nuessler, et al.; Leukemia 13, 1864 (1999), Abstract;
Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier: V.V. Rao, et al.; PNAS 96, 3900 (1999), Abstract; Full Text
Drug resistance-associated markers P-glycoprotein, multidrug resistance-associated protein 1, multidrug resistance-associated protein 2, and lung resistance protein as prognostic factors in ovarian carcinoma: H.J. Arts, et al.; Clin. Cancer Res. 5, 2798 (1999), Abstract; Full Text
Increased expression of multidrug resistance related proteins Pgp, MRP1, and LRP/MVP occurs early in colorectal carcinogenesis: G.A. Meijer, et al.; J. Clin. Pathol. 52, 450 (1999), Abstract;
Reproducible flow cytometric methodology for measuring multidrug resistance in leukaemic blasts: M. Pallis, et al.; Adv. Exp. Med. Biol. 457, 77 (1999), Abstract;
Epitope mapping of monoclonal antibodies specific for the 190-kDa multidrug resistance protein (MRP): D.R. Hipfner, et al.; Br. J. Cancer 78, 1134 (1998), Abstract;
Relationship between major vault protein/lung resistance protein, multidrug resistance-associated protein, P-glycoprotein expression, and drug resistance in childhood leukemia: M.L. Den Boer, et al.; Blood 91, 2092 (1998), Abstract; Full Text
Optimal immunocytochemical and flow cytometric detection of P-gp, MRP and LRP in childhood acute lymphoblastic leukemia: M.L. Den Boer, et al.; Leukemia 11, 1078 (1997), Abstract;
The prognostic significance of expression of the multidrug resistance-associated protein (MRP) in primary breast cancer: K. Nooter, et al.; Br. J. Cancer 76, 486 (1997), Abstract;
Expression of the multidrug resistance-associated protein (MRP) gene in primary non-small-cell lung cancer: K. Nooter, et al.; Ann. Oncol. 7, 75 (1996), Abstract;
Methods to detect P-glycoprotein-associated multidrug resistance in patients' tumors: consensus recommendations: W.T. Beck, et al.; Cancer Res. 56, 3010 (1996), Abstract;
Multidrug resistance-associated protein expression in clinical gastric carcinoma: K. Endo, et al.; Cancer 77, 1681 (1996), Abstract;
Tissue distribution of the multidrug resistance protein: M.J. Flens, et al.; Am. J. Pathol. 148, 1237 (1996), Abstract;
Expression of the multidrug resistance-associated protein (MRP) gene in human cancers: K. Nooter, et al.; Clin. Cancer Res. 1, 1301 (1995), Abstract;
Membrane transport proteins associated with drug resistance expressed in human melanoma: D. Schadendorf, et al.; Am. J. Pathol. 147, 1545 (1995), Abstract;
Detection of the M(r) 190,000 multidrug resistance protein, MRP, with monoclonal antibodies: D.R. Hipfner, et al.; Cancer Res. 54, 5788 (1994), Abstract;
Immunochemical detection of the multidrug resistance-associated protein MRP in human multidrug-resistant tumor cells by monoclonal antibodies: M.J. Flens, et al.; Cancer Res. 54, 4557 (1994), Abstract;
The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump: G.J. Zaman, et al.; PNAS 91, 8822 (1994), Abstract; Full Text

Product Toolbox


Certificate of Analysis


By target:
By biological activity:
MRP Monoclonal antibody
By catalog section:


Technical Service
Customer Service

Related Literature

Product Flyers
Detect Activity of Major ABC Transporter Proteins
Detect Activity of Major ABC Transporter Proteins
Download as PDF

All new literature pieces

Recommend this page

Keep in touch

©2022 Enzo Life Sciences, Inc.,