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(2S,4R)-4-Methylglutamic acid

Kainate receptor agonist
ALX-550-186-M005 5 mg 97.00 USD
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Potent and highly selective kainate receptor agonist, with an IC50 for inhibition of [3H]-kainate binding of 35 nM and almost 3,000- and 200-fold selectivity for kainate receptors over AMPA and NMDA receptors respectively. Also selectively inhibits the cloned excitatory amino acid transporter EAAT2 at higher concentrations.

Product Details

Alternative Name:SYM 2081
Appearance:White powder.
Solubility:Soluble in dilute aqueous acid.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only
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Product Literature References

SYM 2081, an agonist that desensitizes kainate receptors, attenuates capsaicin and inflammatory hyperalgesia: M.S. Turner, et al.; Brain Res. 973, 252 (2003), Abstract;
(2S,4R)-4-methylglutamic acid (SYM 2081): a selective, high-affinity ligand for kainate receptors: L.M. Zhou, et al.; J. Pharmacol. Exp. Ther. 280, 422 (1997), Abstract; Full Text
Synthesis, resolution, and biological evaluation of the four stereoisomers of 4-methylglutamic acid: selective probes of kainate receptors: Z.Q. Gu, et al.; J. Med. Chem. 38, 2518 (1995), Abstract;
Glutamate uptake system in the presynaptic vesicle: glutamic acid analogs as inhibitors and alternate substrates: H.C. Winter & T. Ueda; Neurochem. Res. 18, 79 (1993), Abstract;

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