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5-Aminosalicylic acid

NF-κB pathway inhibitor
ALX-430-110-G005 5 g 98.00 USD
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Inhibits TNF-α regulated IκB degradation and NF-κB activation.

Product Details

Alternative Name:5-ASA, Mesalamine, 5-Amino-2-hydroxybenzoic acid
MI:14: 5904
Purity:≥98% (TLC)
Identity:Determined by IR.
Appearance:White to light gray or light pink powder or crystalline solid.
Solubility:Soluble in 1 M hydrochloric acid.
Shipping:Ambient Temperature
Long Term Storage:+4°C
Handling:Protect from light.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Aminosalicylic acid inhibits IkappaB kinase alpha phosphorylation of IkappaBalpha in mouse intestinal epithelial cells: F. Yan & D.B. Polk; J. Biol. Chem. 274, 36631 (1999), Abstract; Full Text
Inhibition of nuclear factor kappa B and induction of apoptosis in T-lymphocytes by sulfasalazine: S. Liptay, et al.; Br. J. Pharmacol. 128, 1361 (1999), Abstract;