Inhibits TNF-α regulated IκB degradation and NF-κB activation.
Product Details
| Alternative Name: | 5-ASA, Mesalamine, 5-Amino-2-hydroxybenzoic acid |
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| Formula: | C7H7NO3 |
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| MW: | 153.1 |
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| CAS: | 89-57-6 |
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| MI: | 14: 5904 |
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| Purity: | ≥98% (TLC) |
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| Identity: | Determined by IR. |
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| Appearance: | White to light gray or light pink powder or crystalline solid. |
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| Solubility: | Soluble in 1 M hydrochloric acid. |
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| Shipping: | Ambient |
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| Long Term Storage: | +4°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Aminosalicylic acid inhibits IkappaB kinase alpha phosphorylation of IkappaBalpha in mouse intestinal epithelial cells: F. Yan & D.B. Polk; J. Biol. Chem.
274, 36631 (1999),
Abstract;
Full Text
Inhibition of nuclear factor kappa B and induction of apoptosis in T-lymphocytes by sulfasalazine: S. Liptay, et al.; Br. J. Pharmacol.
128, 1361 (1999),
Abstract;
