Replaces Prod. #: BML-CM122
Cell permeable, low molecular weight Bcl-2 ligand. Antagonizes the function of Bcl-2 and induces apoptosis. In HL-60 cells, HA4-1 (50µM and 4h incubation) induced apoptosis of more than 90% of the cells. Apoptosis is blocked by ZVAD-FM. IC50 = ~9µM for competition with Flu-BakBH3 binding to Bcl-2.
Product Details
| Alternative Name: | Ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate |
| |
| Formula: | C17H17BrN2O5 |
| |
| MW: | 409.2 |
| |
| CAS: | 65673-63-4 |
| |
| Purity: | ≥95% (TLC) |
| |
| Identity: | Identity determined by IR, 1H-NMR. |
| |
| Appearance: | Off-white to light yellow powder. |
| |
| Solubility: | Soluble in DMSO (25mg/ml), dimethyl formamide or halogenated solvents; also soluble in 100% ethanol (25mg7ml, hot). |
| |
| Shipping: | Ambient Temperature |
| |
| Long Term Storage: | -20°C |
| |
| Use/Stability: | Unstable in solution. Prepare fresh solution for each application. |
| |
| Handling: | Keep cool and dry. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Please mouse over
Product Literature References
Artesunate induces apoptosis via a ROS-independent and Bax-mediated intrinsic pathway in HepG2 cells: G. Qin, et al.; Exp. Cell Res.
336, 308 (2015),
Application(s): Cell Culture,
Abstract;
Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia: M. Milella, et al.; Blood
99, 3461 (2002),
Abstract;
Synthetic peptides and non-peptidic molecules as probes of structure and function of Bcl-2 family proteins and modulators of apoptosis: D. Liu & Z. Huang; Apoptosis
6, 453 (2001),
Abstract;
Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells: J.L. Wang, et al.; PNAS
97, 7124 (2000),
Abstract;
