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Zinc(II) Protoporphyrin IX

Heme oxygenase inhibitor
ALX-430-049-M005 5 mg 47.00 USD
ALX-430-049-M025 25 mg 85.00 USD
ALX-430-049-M100 100 mg 268.00 USD
Do you need bulk/larger quantities?
Replaces Prod. #: BML-CN235

Potent and selective inhibitor of heme oxygenase (Ki=3nM), the enzyme that generates carbon monoxide (CO). Inhibits soluble guanylyl cyclase. Produces a time- and concentration-dependent inactivation of all three isoforms of nitric oxide synthase (IC50=0.8µM, 4.0µM, and 5.0µM for nNOS (NOS I), iNOS (NOS II) and eNOS (NOS III), respectively). Does not cross the blood-brain barrier. An useful tool to elucidate the role of CO in signal transduction and as a neurotransmitter.

Product Details

Purity:≥95% (TLC)
Identity:Identity determined by UV and NMR.
Appearance:Dark solid.
Solubility:Soluble in pyridine, dimethyl formamide or DMSO. Colloidal in aqueous base;  slightly soluble in aqueous base/organic solvent mixtures.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Use/Stability:Stable for at least 3 years after receipt when stored at -20°C. Make solutions fresh daily. Product may be unstable in solution if exposed to light.
Handling:Protect from light and moisture.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Heme oxygenase-1 in the spinal cord plays crucial roles in the analgesic effects of pregabalin and gabapentin in a spared nerve-injury mouse model: K. Godai, et al.; Neurosci. Lett. 767, 136310 (2022), Abstract;
5-Aminolevulinic acid exerts renoprotective effect via Nrf2 activation in murine rhabdomyolysis-induced acute kidney injury: A. Uchida, et al.; Nephrology (Carlton) 24, 28 (2019), Application(s): Treatment of mice, Abstract;
The apolipoprotein A-I mimetic peptide, D-4F, alleviates ox-LDL-induced oxidative stress and promotes endothelial repair through the eNOS/HO-1 pathway: D. Liu, et al.; J. Mol. Cell. Cardiol. 105, 77 (2017), Abstract;
Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways: C. Zhang, et al.; Redox Biol. 11, 1 (2016), Abstract; Full Text
Cross-talk between two antioxidants, thioredoxin reductase and heme oxygenase-1, and therapeutic implications for multiple myeloma: P.V. Raninga, et al.; Redox Biol. 8, 175 (2016), Application(s): Control of ZnPP IX, Abstract;
Expression of the thioredoxin system in an in vivo-like cancer cell environment upon auranofin treatment: M. Bhatia, et al.; Eur. J. Cell Biol. 95, 378 (2016), Application(s): Evaluation of auranofin induced cytotoxicity, Abstract;
Anti-inflammatory effect of pachymic acid promotes odontoblastic differentiation via HO-1 in dental pulp cells.: Y.H. lee, et al.; Oral Dis. 19, 193 (2013), Application(s): Treatment of human dental pulp cell culture, Abstract;
Heme oxygenase-1 promotes angiogenesis in urothelial carcinoma of the urinary bladder: M. Miyake, et al.; Oncol. Rep. 25, 653 (2011), Application(s): Treatment of human high-grade invasive bladder tumor cell line in culture, Abstract;
Mechanism of inhibition of VIP-induced LES relaxation by heme oxygenase inhibitor zinc protoporphyrin IX: S. Rattan, et al.; Am. J. Physiol. 276, G138 (1999), Abstract; Full Text
Effect of heme oxygenase inhibitors on soluble guanylyl cyclase activity: L. Serfass and J.N. Burstyn; Arch. Biochem. Biophys. 359, 8 (1998), Abstract;
Induction of heme oxygenase-1 expression in vascular smooth muscle cells. A link to endotoxic shock: S.F. Yet, et al.; J. Biol. Chem. 272, 4295 (1997), Abstract; Full Text
Pitfalls using metalloporphyrins in carbon monoxide research: L. Grundemar and L. Ny; TIPS 18, 193 (1997), (Review), Abstract;
Heme oxygenase inhibitor zinc protoporphyrin IX causes an activation of nitric oxide synthase in the rabbit internal anal sphincter: S. Chakder, et al.; J. Pharmacol. Exp. Ther. 277, 1376 (1996), Abstract;
Inhibition of nitric oxide synthase isoforms by porphyrins: D.J. Wolff, et al.; Arch. Biochem. Biophys. 333, 27 (1996), Abstract;
Inhibition by zinc protoporphyrin-IX of receptor-mediated relaxation of the rat aorta in a manner distinct from inhibition of haem oxygenase: L. Ny, et al.; Br. J. Pharmacol. 115, 186 (1995), Abstract;
Preischemic but not postischemic zinc protoporphyrin treatment reduces infarct size and edema accumulation after temporary focal cerebral ischemia in rats: C. Kadoya, et al.; Stroke 26, 1035 (1995), Abstract; Full Text
Does endogenous zinc protoporphyrin modulate carbon monoxide formation from heme? Implications for long-term potentiation, memory, and cognitive function: G.S. Marks, et al.; Can. J. Physiol.Pharmacol. 71, 753 (1993), Abstract;
Nitric oxide and carbon monoxide produce activity-dependent long-term synaptic enhancement in hippocampus: M. Zhuo, et al; Science 260, 1946 (1993), Abstract;
Inhibition of platelet aggregation by carbon monoxide is mediated by activation of guanylate cyclase: B. Brune & V. Ullrich; Mol. Pharmacol. 32, 497 (1987), Abstract;

General Literature References

Gases as biological messengers: nitric oxide and carbon monoxide in the brain: T.M. Dawson & S.H. Snyder; J. Neurosci. 14, 5147 (1994), Abstract;
Carbon monoxide: a putative neural messenger: A. Verma, et al.; Science 259, 381 (1993), Abstract;

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