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Apoptosis Activator 2

Apoptosis inducer
ALX-420-035-M005 5 mg 45.00 USD
ALX-420-035-M025 25 mg 180.00 USD
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Induces apoptosis by promoting the oligomerization of Apaf-1 into the mature, functional apoptosome, triggering caspase-9 activation resulting in activated caspase-3. Shows strong selectivity for cancer cells against normal cell lines. Acts in a similar way like apoptosis inducer PETCM (Prod. No. ALX-420-031).

Product Details

Alternative Name:1-[(3,4-Dichlorophenyl)methyl]-1H-indole-2,3-dione
Purity:≥98% (HPLC)
Appearance:Orange to red solid.
Solubility:Soluble in DMSO (5mg/ml), methanol (5mg/ml) or 100% ethanol.
Shipping:Ambient Temperature
Long Term Storage:+4°C
Regulatory Status:RUO - Research Use Only
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Product Literature References

Autophagy controls the induction and developmental decline of NMDAR-LTD through endocytic recycling : H. Shen, et al.; Nat. Commun. 11, 2979 (2020), Abstract; Full Text
Direct activation of the apoptosis machinery as a mechanism to target cancer cells: J.T. Nguyen and J.A. Wells; PNAS 100, 7533 (2003), Abstract; Full Text

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