Induces apoptosis by promoting the oligomerization of Apaf-1 into the mature, functional apoptosome, triggering caspase-9 activation resulting in activated caspase-3. Shows strong selectivity for cancer cells against normal cell lines. Acts in a similar way like apoptosis inducer PETCM (Prod. No. ALX-420-031).
Product Details
| Alternative Name: | 1-[(3,4-Dichlorophenyl)methyl]-1H-indole-2,3-dione |
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| Formula: | C15H9NO2Cl2 |
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| MW: | 306.1 |
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| CAS: | 79183-19-0 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | Orange to red solid. |
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| MeltingPoint: | 174-175°C |
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| Solubility: | Soluble in DMSO (5mg/ml), methanol (5mg/ml) or 100% ethanol. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Autophagy controls the induction and developmental decline of NMDAR-LTD through endocytic recycling : H. Shen, et al.; Nat. Commun.
11, 2979 (2020),
Abstract;
Full Text
Direct activation of the apoptosis machinery as a mechanism to target cancer cells: J.T. Nguyen and J.A. Wells; PNAS
100, 7533 (2003),
Abstract;
Full Text
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