Antioxidant flavonoid. Inhibitor of mitochondrial ATPase, cAMP- and cGMP-phosphodiesterases. Inhibitor of protein tyrosine kinases and protein kinase C (PKC). Induces apoptosis. Blocks cells at the G0/G1 interface. Activator of human deacetylase SIRT1. Reversible inhibitor of fatty acid synthase (FAS). Inhibits the production of the inflammatory mediators nitric oxide (NO), TNF-α and IL-12 in activated macrophages.Induces gastric relaxation in mouse stomach, mainly by suppressing Ca2+ influx through voltage-dependent calcium channels.
Product Details
| Alternative Name: | 3,3',4',5,7-Pentahydroxyflavone . 2H2O |
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| Formula: | C15H10O7 . 2H2O |
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| MW: | 302.2 . 36.0 |
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| Source: | Isolated from Sophora japonica L. |
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| CAS: | 6151-25-3 |
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| MI: | 14: 8034 |
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| RTECS: | LK8950000 |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | Yellow powder with a green or brown cast. |
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| Solubility: | Soluble in 100% ethanol or 1M sodium hydroxide; almost insoluble in water. |
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| Shipping: | Ambient |
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| Long Term Storage: | Ambient |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Quercetin Inhibits Pacemaker Potentials via Nitric Oxide/cGMP-Dependent Activation and TRPM7/ANO1 Channels in Cultured Interstitial Cells of Cajal from Mouse Small Intestine: H. Gim, et al.; Cell. Physiol. Biochem.
35, 2422 (2015),
Application(s): Cell Culture,
Abstract;
Full Text
Gastric relaxation induced by apigenin and quercetin: Analysis of the mechanism of action: A. Rotondo, et al.; Life Sciences
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Onions: a source of unique dietary flavonoids: R. Slimestad, et al.; J. Agric. Food Chem.
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Inhibitory effects of the flavonoids isolated from Waltheria indica on the production of NO, TNF-alpha and IL-12 in activated macrophages: Y.K. Rao, et al.; Biol. Pharm. Bull.
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Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan: K.T. Howitz, et al.; Nature
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Abstract;
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