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NADPH oxidase inhibitor
ALX-380-321-MC25 0.25 mg 148.00 USD
ALX-380-321-M001 1 mg 475.00 USD
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Antibacterial, antifungal, cytotoxic and antialgal activity. Has been shown to inhibit NADPH oxidase activation in macrophages. Induces apoptosis by phosphorylation of p38 MAP kinase. Additionally, inhibits the association of p47-phox and Rac (NADPH oxidase cytosolic components) to the plasma membrane in macrophages.

Product Details

Alternative Name:Prodigiosine, 4-Methoxy-5-[(5-methyl-4-pentyl-2H-pyrrol-2-ylidene)methyl]-2,2’-bi[1H-pyrrole]
Source:Isolated from Serratia marcescens.
MI:14: 7767
Purity:≥95% (HPLC)
Appearance:Yellow to dark red solid.
Solubility:Soluble in dioxane, pyridine, methylene chloride, hexane, chloroform or methanol; insoluble in water.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Handling:Protect from light.
Regulatory Status:RUO - Research Use Only
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Product Literature References

A prodigiosin analogue inactivates NADPH oxidase in macrophage cells by inhibiting assembly of p47phox and Rac: T. Nakashima, et al. ; J. Biochem. 143, 107 (2008), Abstract;
Mode of action of an antialgal agent produced by a marine gammaproteobacterium against Chattonella marina: T. Nakashima, et al. ; Aquat. Microb. Ecol. 45, 255 (2006), Abstract; Full Text
Producing mechanism of an algicidal compound against red tide phytoplankton in a marine bacterium gamma-proteobacterium: T. Nakashima, et al. ; Appl. Microbiol. Biotechnol. 73, 684 (2006), Abstract;
Apoptosis-mediated cytotoxicity of prodigiosin-like red pigment produced by gamma-Proteobacterium and its multiple bioactivities: T. Nakashima, et al. ; Biol. Pharm. Bull. 28, 2289 (2005), Abstract;
Characterization of bacterium isolated from the sediment at coastal area of Omura Bay in Japan and several biological activities of pigment produced by this isolate: T. Nakashima, et al. ; Microbiol. Immunol. 49, 407 (2005), Abstract;
Evaluation of the anti-Trichophyton activity of a prodigiosin analogue produced by gamma-proteobacterium, using stratum corneum epidermis of the Yucatan micropig: T. Nakashima, et al.; J. Infect. Chemother. 11, 123 (2005), Abstract;