Fluoroquinolone with broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria.
Product Details
| Alternative Name: | 6-Fluoro-1-methyl-7-[4-[(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl]-1-piperazinyl]-4-oxo-1H,4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid, NM441 |
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| Formula: | C21H20FN3O6S |
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| MW: | 461.5 |
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| CAS: | 123447-62-1 |
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| MI: | 14: 7908 |
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| Purity: | ≥98% (Assay) |
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| Identity: | Determined by IR. |
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| Appearance: | White to yellow crystalline solid. |
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| Solubility: | Slightly soluble in dimethyl formamide, 0.1M NaOH or glacial acetic acid; insoluble in water or methanol. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Pharmacologic characteristics of prulifloxacin: M.G. Matera; Pulm. Pharmacol. Ther.
19, 20 (2006),
Abstract;
Prulifloxacin: a new antibacterial fluoroquinolone: G. Prats, et al.; Expert. Rev. Anti. Infect. Ther.
4, 27 (2006), (Review),
Abstract;
Prulifloxacin: a new fluoroquinolone for the treatment of acute exacerbation of chronic bronchitis: M. Cazzola, et al.; Pulm. Pharmacol. Ther.
19, 30 (2006),
Abstract;
Randomized, double-blind study of prulifloxacin versus ciprofloxacin in patients with acute exacerbations of chronic bronchitis: C. Grassi, et al.; Respiration
69, 217 (2002),
Abstract;
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Pharmacokinetics and safety of NM441, a new quinolone, in healthy male volunteers: M. Nakashima, et al.; J. Clin. Pharmacol.
34, 930 (1994),
Abstract;
Studies on pyridonecarboxylic acids. 1. Synthesis and antibacterial evaluation of 7-substituted-6-halo-4-oxo-4H-[1,3]thiazeto[3,2-a]quinoline-3- carboxylic acids: J. Segawa, et al.; J. Med. Chem.
35, 4727 (1992),
Abstract;
In vivo evaluation of NM441, a new thiazeto-quinoline derivative: M. Ozaki, et al.; Antimicrob. Agents Chemother.
35, 2496 (1991),
Abstract;
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