Polymyxin antibiotic. Binds to lipids on the cell cytoplasmic membrane. Disrupts cell wall integrity. Effective against Gram-negative bacteria.
Product Details
| Alternative Name: | Polymyxin E . sulfate |
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| Source: | Isolated from Bacillus colistinus. |
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| CAS: | 1264-72-8 |
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| MI: | 14: 2479 |
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| RTECS: | TR1500000 |
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| Purity Detail: | Mixture of >30 compounds, primarily colistin A and B. |
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| Appearance: | White to off-white powder. |
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| Activity: | Potency is >19'900 u/mg (on dry basis). |
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| Solubility: | Soluble in water (50mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Colistin B
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Product Literature References
Polymyxins: wisdom does not always come with age: Z. Kassamali, et al.; Clin. Infect. Dis.
57, 877 (2013),
Abstract;
The clinical use of colistin in patients with cystic fibrosis: P. Beringer; Curr. Opin. Pulm. Med.
7, 434 (2001), (Review),
Abstract;
Polymyxin B sulfate and colistin: old antibiotics for emerging multiresistant gram-negative bacteria: M.E. Evans, et al.; Ann. Pharmacother.
33, 960 (1999), (Review),
Abstract;
Antibacterial action of colistin (polymyxin E) against Mycobacterium aurum: H.L. David & N. Rastogi; Antimicrob. Agents Chemother.
27, 701 (1985),
Abstract;
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