Inhibitor of protein kinase C (PKC) and cyclin-dependent kinases (CDKs) resulting in accumulation of cells in the G1 phase and induction of apoptosis. Enhances the cytotoxicity of other anticancer drugs, such as DNA-damaging agents and anti-metabolite drugs, through putative abrogation of G2 and/or S phase accumulation induced by these agents.
Product Details
| Alternative Name: | 7-Hydroxystaurosporine |
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| Formula: | C28H26N4O4 |
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| MW: | 482.5 |
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| Source: | Isolated from Streptomyces sp. MST-AS5345. |
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| CAS: | 112953-11-4 |
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| RTECS: | KC6600010 |
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| Purity: | ≥99% (HPLC) |
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| Appearance: | White film. |
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| Solubility: | Soluble in methanol, 100% ethanol, dimethyl formamide or DMSO. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. |
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| Technical Info/Product Notes: | Note: Some interconversion of UCN-01 to UCN-02 may occur under acidic HPLC conditions). |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Dual roles of ERK1/2 in cellular senescence induced by excess thymidine in HeLa cells: I. Kudo, et al.; Exp. Cell. Res.
16, 30205 (2016),
Application(s): Cell culture, cervical tumor,
Abstract;
UCN-01-induced cell cycle arrest requires the transcriptional induction of p21(waf1/cip1) by activation of mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase pathway: M.M. Facchinetti, et al.; Cancer Res.
64, 3629 (2004),
Abstract;
Full Text
UCN-01 (7-hydroxystaurosporine) and other indolocarbazole compounds: a new generation of anti-cancer agents for the new century?: S. Akinaga, et al.; Anticancer Drug Des.
15, 43 (2000),
Abstract;
UCN-01, 7-hydroxyl-staurosporine, inhibits kinase activity of cyclin-dependent kinases and reduces the phosphorylation of the retinoblastoma susceptibility gene product in A549 human lung cancer cell line: K. Kawakami, et al.; BBRC
219, 778 (1996),
Abstract;
UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities: I. Takahashi, et al.; J. Antibiot. (Tokyo)
42, 571 (1989),
Abstract;
UCN-01, a selective inhibitor of protein kinase C from Streptomyces: I. Takahashi, et al.; J. Antibiot. (Tokyo)
40, 1782 (1987),
Abstract;
