Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Antimycin A

ALX-380-075-M005 5 mg 45.00 USD
ALX-380-075-M010 10 mg 52.00 USD
Do you need bulk/larger quantities?
  • Antimycin A complex composed mostly of Antimycin A1, A2, A3, and A4
  • Used for the study of the mitochondrial function
Antimycin A is a bacterial metabolite complex produced by Streptomyces. It is composed majorly of Antimycin A1, A2, A3, and A4. Antimycin A is an antibiotic. It is capable of inducing apoptosis in mammalian cells, which is not prevented by the presence of Bcl-2. Antimycin A acts as an inhibitor of cellular respiration and more specifically, the electron transport chain of oxidative phosphorylation via its binding to cytochrome c reductase.

Product Details

Alternative Name:Antipiricullin, Virosin
Source:Isolated from Streptomyces sp. Mixture of antimycin A's.
MI:14: 714 (A1) & 715 (A3)
Identity:Identity determined by NMR.
Appearance:White to faint yellow powder.
Solubility:Soluble in 100% ethanol (50mg/ml).
Shipping:Ambient Temperature
Long Term Storage:-20°C
Handling:Protect from light.
Regulatory Status:RUO - Research Use Only
Please mouse over

Product Literature References

Near-anoxia induces immobilization and sustains viability of sperm stored in ant queens: A. Gotoh, et al.; Sci. Rep. 13, 3029 (2023), Abstract;
Oxidative metabolism is impaired by phosphate deficiency during fracture healing and is mechanistically related to BMP induced chondrocyte differentiation: A.I. Hussein, et al.; Bone Rep. 18, 101657 (2023), Abstract;
The phloroglucinol calcitrinone A, a novel mitochondria-targeting agent, induces cell death in breast cancer cells: M.E. Gaafary, et al.; Food Chem. Toxicol. 162, 112896 (2022), Abstract;
Macrophage HIF-2α suppresses NLRP3 inflammasome activation and alleviates insulin resistance: X. Li, et al.; Cell Rep. 36, 109607 (2021), Abstract;
Unexpected Role of Sterol Synthesis in RNA Stability and Translation in Leishmania: Z. N. Karamysheva, et al.; Biomedicines 19, 696 (2021), Abstract;
COQ11 deletion mitigates respiratory deficiency caused by mutations in the gene encoding the coenzyme Q chaperone protein Coq10: M.C. Bradley, et al.; J. Biol. Chem. 295, 6023 (2020), Abstract; Full Text
Dihydroartemisinin induces growth arrest and overcomes dexamethasone resistance in multiple myeloma: Y. Chen, et al.; Front. Oncol. 10, 767 (2020), Abstract; Full Text
Loss of Peter Pan (PPAN) affects mitochondrial homeostasis and autophagic flux: D.P. Dannheisig, et al.; Cells 8, 894 (2019), Abstract; Full Text
Mitochondrial dysfunction causes Ca2+ overload and ECM degradation–mediated muscle damage in C. elegans: S. Sudevan, et al.; FASEB J. 33, 9540 (2019), Abstract; Full Text
Spatially stable mitochondrial compartments fuel local translation during plasticity: V. Rangaraju, et al.; Cell 176, 73 (2019), Abstract;
Measurement of oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) in culture cells for assessment of the energy metabolism: B. Plizko, et al.; Bio. Protoc. 8, e2850 (2018), Abstract; Full Text
UBXD1 is a mitochondrial recruitment factor for p97/VCP and promotes mitophagy: A.C. Bento, et al.; Sci. Rep. 8, 12415 (2018), Abstract; Full Text
The Natural Product Mensacarcin Induces Mitochondrial Toxicity and Apoptosis in Melanoma Cells: B. Plitzko, et al.; J. Biol. Chem. 292, 21102 (2017), Abstract; Full Text
The effect of phosphate availability on chondrocyte metabolic function: K. Blank, et al.; (2016), (master's thesis), Application(s): Inhibitor of complex III in the electron transport chain, Full Text
An ROS generator, antimycin A, inhibits the growth of HeLa cells via apoptosis: W.H. Park, et al.; J. Cell. Biochem. 102, 98 (2007), Abstract;
Oligomycin and antimycin A prevent nitric oxide-induced apoptosis by blocking cytochrome C leakage: N. Dairaku, et al.; J. Lab. Clin. Med. 143, 143 (2004), Abstract;
Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3: S.P. Tzung, et al.; Nat. Cell. Biol. 3, 183 (2001), Abstract;
Biophysical characterization of recombinant human Bcl-2 and its interactions with an inhibitory ligand, antimycin A: K.M. Kim, et al.; Biochemistry 40, 4911 (2001), Abstract;
Synthetic peptides and non-peptidic molecules as probes of structure and function of Bcl-2 family proteins and modulators of apoptosis: D. Liu & Z. Huang; Apoptosis 6, 453 (2001), Abstract;
The effect of antimycin A on mouse liver inner mitochondrial membrane channel activity: M.L. Campo, et al.; J. Biol. Chem. 267, 8123 (1992), Abstract; Full Text
The isolation and properties of antimycin A: B. R. Dunshee, et al.; J. Am. Chem. Soc. 71, 2436 (1949),