Replaces Prod. #: BML-GR306
A selective inhibitor of bacterial DNA-dependent RNA polymerase (RNAP). Has no effect on mammalian RNA polymerase. The RNAP-rifampicin complex locks the promoter in an abortive initiation reaction making short oligoribonucleotides which diffuse out of the active site. Inhibits α-synuclein fibrillation and disaggregates fibrils. Potent inducer of hepatic cytochrome P450 enzymes.
Product Details
| Alternative Name: | Rifampin, 3-(4-Methylpiperazinyl-iminomethyl)rifamycin SV |
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| Formula: | C43H58N4O12 |
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| MW: | 823.0 |
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| Source: | Semisynthetic. |
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| CAS: | 13292-46-1 |
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| MI: | 14: 8216 |
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| RTECS: | VJ7000000 |
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| Purity: | ≥97% (Assay) |
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| Appearance: | Orange to brown powder. |
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| Solubility: | Soluble in DMSO (25mg/ml) or methanol (25mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptor: J. Chen and K. Raymond; Ann. Clin. Microbiol. Antimicrob.
50, 3 (2006), Review,
Abstract;
Rifampicin inhibits alpha-synuclein fibrillation and disaggregates fibrils: J. Li, et al.; Chem. Biol.
11, 1513 (2004),
Abstract;
Pharmacokinetic interactions with rifampicin : clinical relevance: M. Niemi, et al.; Clin. Pharmacokinet.
42, 819 (2003), Review,
Abstract;
Rifampicin region revisited. New rifampicin-resistant and streptolydigin-resistant mutants in the beta subunit of Escherichia coli RNA polymerase: K. Severinov, et al.; J. Biol. Chem.
268, 14820 (1993),
Abstract;
Pharmacokinetic drug interactions with rifampicin: K. Venkatesan; Clin. Pharmacokinet.
22, 47 (1992), Review,
Abstract;
On the mechanism of rifampicin inhibition of RNA synthesis: W.R. McClure and C.L. Cech; J. Biol. Chem.
253, 8949 (1978),
Abstract;
Chemical and biological properties of rifampicin: S. Furesz; Antibiot. Chemother.
16, 316 (1970),
Abstract;
Rifampicin sensitivity of the components of DNA-dependent RNA polymerase: E. di Mauro, et al.; Nature
222, 533 (1969),
Abstract;
Rifampicin: a new orally active rifamycin: N. Maggi, et al.; Chemotherapy
11, 285 (1966),
Abstract;
