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Monensin . sodium salt

Na+ ionophore
ALX-380-026-M100 100 mg 45.00 USD
ALX-380-026-G001 1 g 94.00 USD
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Replaces Prod. #: BML-A248

Antibiotic that functions as Na+ ionophore. Blocks glycoprotein secretion. Inhibits proliferation of several lymphoma cell lines through cell cycle arrest and apoptosis. Blocks ceramide transport through the Golgi apparatus.

Product Details

Formula:C36H61O11 . Na
MW:669.9 . 23.0
MI:14: 6246
Appearance:White to light yellow powder.
Solubility:Soluble in 100% ethanol (25mg/ml), methanol (50mg/ml), chloroform or DMSO (25mg/ml). Slightly soluble in water.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Handling:Store tightly sealed in the dark.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Elevated Th22 cells and related cytokines in patients with epithelial ovarian cancer: T. Wang, et al.; Medicine (Baltimore) 96, e8359 (2017), Application(s): Flow Cytometry, Abstract; Full Text
Image-based drug screen identifies HDAC inhibitors as novel Golgi disruptors synergizing with JQ1: M. Gendarme, et al.; Mol. Biol. Cell. 28, 3756 (2017), Abstract; Full Text
Increased Th9 cells and IL-9 levels accelerate disease progression in experimental atherosclerosis: Q. Li, et al.; Am. J. Transl. Res. 9, 1335 (2017), Abstract; Full Text
Interleukin-37 and Dendritic Cells Treated With Interleukin-37 Plus Troponin I Ameliorate Cardiac Remodeling After Myocardial Infarction: R. Zhu, et al.; J. Am. Heart Assoc. 5, e004406 (2016), Abstract; Full Text
Olfactory ecto-mesenchymal stem cells possess immunoregulatory function and suppress autoimmune arthritis: K. Rui, et al.; Cell. Mol. Immunol. 13, 401 (2015), Application(s): Flow cytometric analysis in mouse cells, Abstract;
The Profile of T Helper Subsets in Bone Marrow Microenvironment Is Distinct for Different Stages of Acute Myeloid Leukemia Patients and Chemotherapy Partly Ameliorates These Variations: T. Tian, et al.; PLoS One 10, e0131761 (2015), Application(s): Cell Culture, Abstract; Full Text
Monensin-mediated growth inhibition in human lymphoma cells through cell cycle arrest and apoptosis: W. H. Park, et al.; Br. J. Haematol. 119, 400 (2002), Abstract;
Monensin inhibits synthesis of plasma membrane sphingomyelin by blocking transport of ceramide through the Golgi: evidence for two sites of sphingomyelin synthesis in BHK cells: K.J. Kallen et al.; Biochim. Biophys. Acta 1166, 305 (1993), Abstract;
Sphingomyelin transport to the cell surface occurs independently of protein secretion in rat hepatocytes: Y.J. Shiao & J.E. Vance; J. Biol. Chem. 268, 26085 (1993), Abstract;
Alteration of intracellular traffic by monensin; mechanism, specificity and relationship to toxicity: H. H. Mollenhauer, et al.; Biochim. Biophys. Acta 1031, 225 (1990), Review, Abstract;
Expression of membrane IGM by a human B lymphoblastoid cell line in the presence of monensin: R.T. Kubo and M.L. Pigeon; Mol. Immunol. 20, 345 (1983), Abstract;
Undersulfated proteoglycans are secreted by cultured chondrocytes in the presence of the ionophore monensin: K. Tajiri, et al.; J. Biol. Chem. 255, 6036 (1980), Abstract; Full Text
Solution chemistry of monensin and its alkali metal ion complexes. Potentiometric and spectroscopic studies: P.G. Gertenbach & A.I. Popov; JACS 97, 4738 (1975), Abstract;
Monensin, a new biologically active compound. I. Discovery and isolation: M. E. Haney, Jr. & M. M. Hoehn; Antimicrobial Agents Chemother. (Bethesda) 7, 349 (1967), Abstract;

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