Replaces Prod. #: BML-CM117
Insecticide. Inhibitor of mitochondrial electron transport. Specifically inhibits NAD-linked substrate oxidation at the oxygen side of NADH dehydrogenase (EC50=10pmol/mg). Inhibits mammalian cell proliferation by inhibiting microtubule assembly through tubulin binding. Can inhibit mitochondrial swelling and cytochrome c release induced by N-methyl-4-phenylpyridinium.
Product Specification
| Formula: | C23H22O6 |
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| MW: | 394.4 |
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| Source: | Isolated from Lonchocarpus sp. or Derris sp. |
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| CAS: | 83-79-4 |
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| MI: | 14: 8271 |
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| RTECS: | DJ2800000 |
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| Purity: | ≥97% (UHPLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in DMSO or 100% ethanol; slightly soluble in water. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Protection by the NDI1 Gene against Neurodegeneration in a Rotenone Rat Model of Parkinson’s Disease: M. Marella, et al.; PLoS ONE
3, e1433 (2008),
Abstract;
Full Text
Identification of novel proteins affected by rotenone in mitochondria of dopaminergic cells: J. Jin, et al.; BMC Neurosci.
8, 67 (2007),
Abstract;
Full Text
Rotenone inhibits mammalian cell proliferation by inhibiting microtubule assembly through tubulin binding: P. Srivastava & D. Panda; FEBS J.
274, 4788 (2007),
Abstract;
Neurotrophic factors stabilize microtubules and protect against rotenone toxicity on dopaminergic neurons: Q. Jiang, et al.; J. Biol. Chem.
281, 29391 (2006),
Abstract;
Fatality after deliberate ingestion of the pesticide rotenone: a case report: D.M. Wood, et al.; Crit Care
9, R280 (2005),
Abstract;
Full Text
Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures: C.M. Testa, et al.; Brain Res. Mol. Brain Res.
134, 109 (2005),
Abstract;
Full Text
The parkinsonian neurotoxin MPP+ opens the mitochondrial permeability transition pore and releases cytochrome c in isolated mitochondria via an oxidative mechanism: D.S. Cassarino, et al.; Biochim. Biophys. Acta
1453, 49 (1999),
Abstract;
Inhibition of mitochondrial respiratory chain complex I by TNF results in cytochrome c release, membrane permeability transition, and apoptosis: M. Higuchi, et al.; Oncogene
17, 2515 (1998),
Abstract;
[3H]dihydrorotenone binding to NADH: ubiquinone reductase (complex I) of the electron transport chain: an autoradiographic study: D.S. Higgins, Jr. & J.T. Greenamyre; J. Neurosci.
16, 3807 (1996),
Abstract;
Full Text
Metabolism of rotenone in vitro by tissue homogenates from mammals and insects: J.I. Fukami, et al.; Science
155, 713 (1967),
Abstract;
