Replaces Prod. #: BML-CM117
Insecticide. Inhibitor of mitochondrial electron transport. Specifically inhibits NAD-linked substrate oxidation at the oxygen side of NADH dehydrogenase (EC50=10pmol/mg). Inhibits mammalian cell proliferation by inhibiting microtubule assembly through tubulin binding. Can inhibit mitochondrial swelling and cytochrome c release induced by N-methyl-4-phenylpyridinium.
Product Details
| Formula: | C23H22O6 |
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| MW: | 394.4 |
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| Source: | Isolated from Lonchocarpus sp. or Derris sp. |
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| CAS: | 83-79-4 |
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| MI: | 14: 8271 |
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| RTECS: | DJ2800000 |
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| Purity: | ≥97% (UHPLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in DMSO or 100% ethanol; slightly soluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Rotenone inhibits mammalian cell proliferation by inhibiting microtubule assembly through tubulin binding: P. Srivastava & D. Panda; FEBS J.
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Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures: C.M. Testa, et al.; Brain Res. Mol. Brain Res.
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The parkinsonian neurotoxin MPP+ opens the mitochondrial permeability transition pore and releases cytochrome c in isolated mitochondria via an oxidative mechanism: D.S. Cassarino, et al.; Biochim. Biophys. Acta
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Metabolism of rotenone in vitro by tissue homogenates from mammals and insects: J.I. Fukami, et al.; Science
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