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ALX-350-360-G001 1 g 79.00 USD
ALX-350-360-G005 5 g 246.00 USD
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Replaces Prod. #: BML-CM117

Insecticide. Inhibitor of mitochondrial electron transport. Specifically inhibits NAD-linked substrate oxidation at the oxygen side of NADH dehydrogenase (EC50=10pmol/mg). Inhibits mammalian cell proliferation by inhibiting microtubule assembly through tubulin binding. Can inhibit mitochondrial swelling and cytochrome c release induced by N-methyl-4-phenylpyridinium.

Product Details

Source:Isolated from Lonchocarpus sp. or Derris sp.
MI:14: 8271
Purity:≥97% (UHPLC)
Appearance:White to off-white solid.
Solubility:Soluble in DMSO or 100% ethanol; slightly soluble in water.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Handling:Protect from light.
Regulatory Status:RUO - Research Use Only
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Product Literature References

NF-κB–Inducing Kinase Governs the Mitochondrial Respiratory Capacity, Differentiation, and Inflammatory Status of Innate Immune Cells: J.N. Keeney, et al.; J. Immunol. 210, 1123 (2023), Abstract;
Carbon Monoxide Releasing Molecule-3 Enhances Heme Oxygenase-1 Induction via ROS-Dependent FoxO1 and Nrf2 in Brain Astrocytes: C. C. Lin, et al.; Oxid. Med. Cell. Longev. 2021, 5521196 (2021), Abstract;
Loss of Ubiquitin Carboxy-Terminal Hydrolase L1 Impairs Long-Term Differentiation Competence and Metabolic Regulation in Murine Spermatogonial Stem Cells: W.F. Alpaugh, et al.; Cells 10, 2265 (2021), Abstract;
Unique metabolic phenotype and its transition during maturation of juvenile male germ cells: A.L. Voigt, et al.; FASEB J. 15, 21513 (2021), Abstract;
Protection by the NDI1 Gene against Neurodegeneration in a Rotenone Rat Model of Parkinson’s Disease: M. Marella, et al.; PLoS ONE 3, e1433 (2008), Abstract; Full Text
Identification of novel proteins affected by rotenone in mitochondria of dopaminergic cells: J. Jin, et al.; BMC Neurosci. 8, 67 (2007), Abstract; Full Text
Rotenone inhibits mammalian cell proliferation by inhibiting microtubule assembly through tubulin binding: P. Srivastava & D. Panda; FEBS J. 274, 4788 (2007), Abstract;
Neurotrophic factors stabilize microtubules and protect against rotenone toxicity on dopaminergic neurons: Q. Jiang, et al.; J. Biol. Chem. 281, 29391 (2006), Abstract;
Fatality after deliberate ingestion of the pesticide rotenone: a case report: D.M. Wood, et al.; Crit Care 9, R280 (2005), Abstract; Full Text
Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures: C.M. Testa, et al.; Brain Res. Mol. Brain Res. 134, 109 (2005), Abstract; Full Text
The parkinsonian neurotoxin MPP+ opens the mitochondrial permeability transition pore and releases cytochrome c in isolated mitochondria via an oxidative mechanism: D.S. Cassarino, et al.; Biochim. Biophys. Acta 1453, 49 (1999), Abstract;
Inhibition of mitochondrial respiratory chain complex I by TNF results in cytochrome c release, membrane permeability transition, and apoptosis: M. Higuchi, et al.; Oncogene 17, 2515 (1998), Abstract;
[3H]dihydrorotenone binding to NADH: ubiquinone reductase (complex I) of the electron transport chain: an autoradiographic study: D.S. Higgins, Jr. & J.T. Greenamyre; J. Neurosci. 16, 3807 (1996), Abstract; Full Text
Metabolism of rotenone in vitro by tissue homogenates from mammals and insects: J.I. Fukami, et al.; Science 155, 713 (1967), Abstract;

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By target:
Mitochondrial complex
By biological activity:
Mitochondrial complex Inhibitor
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