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Gramicidin A

Ionophore antibiotic
ALX-350-233-M001 1 mg 56.00 USD
ALX-350-233-M005 5 mg 115.00 USD
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Naturally occurring ion channel forming pentadecapeptide. Causes K+/H+-exchange in mitochondria in a non-voltage dependent manner.

Product Details

Source:Isolated from Bacillus brevis.
MI:14: 4532
Purity:≥90% (HPLC)
Purity Detail:Contaminants: ≤5% Gramicidin C (HPLC).
Appearance:White to off-white powder.
Solubility:Soluble in DMSO, lower alcohols or acetic acid.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only

Product Literature References

The ionophore antibiotic gramicidin A inhibits pancreatic cancer stem cells associated with CD47 down-regulation: R.Q. Wang, et al.; Cancer Cell Int. 19, 145 (2019), Abstract; Full Text
Effects of gramicidin-A on the adsorption of phospholipids to the air-water interface: S.C. Biswas, et al.; Biochim. Biophys. Acta 1717, 41 (2005), Abstract;
Two mechanisms of H+/OH- transport across phospholipid vesicular membrane facilitated by gramicidin A: B.S. Prabhananda & M.H. Kombrabail; Biophys. J. 71, 3091 (1996), Abstract;
Palmitoylation-induced conformational changes of specific side chains in the gramicidin transmembrane channel: R.E. Koeppe, 2nd, et al.; Biochemistry 34, 9299 (1995), Abstract;
The permeation properties of small organic cations in gramicidin A channels: S.A. Seoh & D. Busath; Biophys. J. 64, 1017 (1993), Abstract;
Purification of gramicidin A: C.J. Stankovic, et al.; Anal. Biochem. 184, 100 (1990), Abstract;

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