Naturally occurring ion channel forming pentadecapeptide. Causes K+/H+-exchange in mitochondria in a non-voltage dependent manner.
Product Details
| Sequence: | HCO-Val-Gly-Ala-D-Leu-Ala-D-Val-Val-D-Val-Trp-D-Leu-Trp-D-Leu-Trp-D-Leu-Trp-NHCH2CH2OH |
| |
| Formula: | C99H140N20O17 |
| |
| MW: | 1882.3 |
| |
| Source: | Isolated from Bacillus brevis. |
| |
| CAS: | 11029-61-1 |
| |
| MI: | 14: 4532 |
| |
| RTECS: | MD8230000 |
| |
| Purity: | ≥90% (HPLC) |
| |
| Purity Detail: | Contaminants: ≤5% Gramicidin C (HPLC). |
| |
| Appearance: | White to off-white powder. |
| |
| Solubility: | Soluble in DMSO, lower alcohols or acetic acid. |
| |
| Shipping: | Ambient Temperature |
| |
| Long Term Storage: | -20°C |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Product Literature References
The ionophore antibiotic gramicidin A inhibits pancreatic cancer stem cells associated with CD47 down-regulation: R.Q. Wang, et al.; Cancer Cell Int.
19, 145 (2019),
Abstract;
Full Text
Effects of gramicidin-A on the adsorption of phospholipids to the air-water interface: S.C. Biswas, et al.; Biochim. Biophys. Acta
1717, 41 (2005),
Abstract;
Two mechanisms of H+/OH- transport across phospholipid vesicular membrane facilitated by gramicidin A: B.S. Prabhananda & M.H. Kombrabail; Biophys. J.
71, 3091 (1996),
Abstract;
Palmitoylation-induced conformational changes of specific side chains in the gramicidin transmembrane channel: R.E. Koeppe, 2nd, et al.; Biochemistry
34, 9299 (1995),
Abstract;
The permeation properties of small organic cations in gramicidin A channels: S.A. Seoh & D. Busath; Biophys. J.
64, 1017 (1993),
Abstract;
Purification of gramicidin A: C.J. Stankovic, et al.; Anal. Biochem.
184, 100 (1990),
Abstract;
