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R,S-Sulforaphane

Carcinogenesis inhibitor
 
ALX-350-232-M025 25 mg 203.00 USD
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R,S-Sulforaphane is a synthetic version of the naturally occurring compound, R-sulforaphane, from Broccoli. It is a racemic mixture of both the R and S isomers.
Potent, selective inducer of phase II detoxification enzymes. Inhibits chemically induced mammary tumor formation in rats. Inhibits LPS-induced HMGB1 (high mobility group box 1) secretion.

Product Details

Alternative Name:D,L-Sulforaphane, 1-Isothiocyanato-4-methylsulfinyl-butane
 
Formula:C6H11NOS2
 
MW:177.3
 
Source:Synthetic.
 
CAS:4478-93-7 (unspecified stereo)
 
MI:14: 8962
 
Purity:≥98% (UHPLC)
 
Identity:Identity determined by 1H-NMR and MS.
 
Appearance:Slightly yellowish liquid.
 
Solubility:Soluble in methanol or DMSO.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Regulatory Status:RUO - Research Use Only
 
350-232
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350-232

Product Literature References

Simultaneous quantification of sulforaphene and sulforaphane by reverse phase HPLC and their content in Raphanus sativus L. var. caudatus Alef extracts: S. Sangthong, et al.; Food. Chem. 201, 139 (2016), Application(s): Standard, Abstract;
4-Methylthiobutyl isothiocyanate (Erucin) from rocket plant dichotomously affects the activity of human immunocompetent cells: C. Gründemann, et al.; Phytomedicine 22, 369 (2015), Application(s): Gas Chromatography - Mass Spectrometry , Abstract;
Synergy between sulforaphane and selenium in protection against oxidative damage in colonic CCD841 cells: Y. Wang, et al.; Nutr. Res. 35, 610 (2015), Abstract;
Protective effect of sulforaphane against oxidative stress: Recent advances: C.E. Guerrero-Beltran, et al.; Exp. Toxicol. Pathol. 64, 503 (2012), Abstract;
Sulforaphane targets pancreatic tumor-initiating cells by NF-{kappa}B-induced anti-apoptotic signaling: G. Kallifatidis, et al.; Gut 58, 949 (2009), Abstract;
The phase 2 enzyme inducers ethacrynic acid, DL-sulforaphane, and oltipraz inhibit lipopolysaccharide-induced high-mobility group box 1 secretion by RAW 264.7 cells: M.E. Killeen, et al.; J. Pharmacol. Exp. Ther. 316, 1070 (2006), Abstract;
A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase: M.C. Myzak, et al.; Cancer Res. 64, 5767 (2004), Abstract; Full Text
Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates: Y. Zhang, et al.; PNAS 91, 3147 (1994), Abstract; Full Text
A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure: Y. Zhang, et al.; PNAS 89, 2399 (1992), Abstract; Full Text

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