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Nodularin (linear)

Precursor of the highly toxic cyclic pentapeptide, nodularin.
ALX-350-182-C100 100 µg 274.00 USD
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Linear nodularin has been demonstrated to be a biosynthetic precursor of the highly toxic cyclic pentapeptide, nodularin. It is an intermediate of biodegradation by natural populations of bacteria in aquatic samples.

Product Details

Source:Isolated from Nodularia spumigena.
Purity:≥95% (HPLC)
Identity:Identity determined by MS.
Appearance:Pale powder or an oil (film), depending on the lot.
Solubility:Soluble in methanol:water (1:1).
Shipping:Ambient Temperature
Long Term Storage:-20°C
Technical Info/Product Notes:Not toxic to mice at 2 mg/kg I.P.
Regulatory Status:RUO - Research Use Only
350-182 01
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350-182 01

Product Literature References

An ELISA-based Method for Variant-independent Detection of Total 3 Microcystins and Nodularins via Multi-immunogen Approach: J. Liu, et al.; Environ. Sci. Technol. 55, 12984 (2021), Abstract;
Biodegradation of microcystins and nodularin in freshwaters: C. Edwards, et al.; Chemosphere 73, 1315 (2008), Abstract;
Characterization of nodularin variants in Nodularia spumigena from the Baltic Sea using liquid chromatography/mass spectrometry/mass spectrometry: H. Mazur-Marzec, et al.; Rapid Commun. Mass Spectrom. 20, 2023 (2006), Abstract;
Nodularin-induced genotoxicity following oxidative DNA damage and aneuploidy in HepG2 cells: A. Lankoff, et al.; Toxicol. Lett. 164, 239 (2006), Abstract;
Bacterial degradation of microcystins and nodularin: S. Imanishi, et al.; Chem. Res. Toxicol. 18, 591 (2005), Abstract;
New Nodularins: A General Method for Structure Assignment: M. Namikoshi, et al.; J. Org. Chem. 59, 2349 (1994), Full Text
Structure and Biosynthesis of toxins from blue-green algae: K.L. Rinehart, et al.; J. Appl. Phycol. 6, 159 (1994),
Isolation of linear peptides related to the hepatotoxins nodularin and microcystins: B.W. Choi, et al; Tetrahed. Lett. 34, 7881 (1993),

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