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Ouabain . octahydrate

Na+/K+ ATPase inhibitor
ALX-350-066-M100 100 mg 45.00 USD
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Replaces Prod. #: BML-CM109

A steroidal inhibitor of cardiac sodium pumps (Na+/K+ ATPase) which has been recognized as an endogenous adrenal hormone. In the CNS it can be used as a tool to induce in vivo excitotoxicity. Ouabain, as well as other endogenous digitalis-like compounds, can down-regulate the expression of 14-3-3 proteins in rat lens.

Product Details

Alternative Name:Strophanthin G, 3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-1,5,11α-14,19-penta-hydroxycard-20(22)-enolide
Formula:C29H44O12 . 8H2O
MW:584.6 . 144.2
MI:14: 6901
Purity:≥98% (TLC)
Appearance:White solid.
Solubility:Soluble in water (>25mg/ml).
Shipping:Ambient Temperature
Long Term Storage:+4°C
Handling:Protect from light.
Regulatory Status:RUO - Research Use Only
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Product Literature References

ATP-binding cassette subfamily B member 1 (ABCB1) and subfamily C member 10 (ABCC10) are not primary resistance factors for cabazitaxel: R.J. Kathawala, et al.; Chin. J. Cancer 34, 5 (2015), Application(s): Cell Culture, Abstract; Full Text
Anti-inflammatory and antinociceptive activity of ouabain in mice: D.I. de Vasconcelos, et al.; Mediators Inflamm. 2011, 912925 (2011), Abstract; Full Text
Na+,K+-ATPase and hormone ouabain:new roles for an old enzyme and an old inhibitor: R.G. Contreras, et al.; Cell. Mol. Biol. 52, 31 (2006), (Review), Abstract;
Vascular endothelium as a target for endogenous ouabain: studies on the effect of ouabain on human endothelial cells: L. Trevisi, et al.; Cell. Mol. Biol. 52, 64 (2006), (Review), Abstract;
Cardiotonic steroids differentially affect intracellular Na+ and [Na+]i/[K+]i-independent signaling in C7-MDCK cells: O.A. Akimova, et al.; J. Biol. Chem. 280, 832 (2005), Abstract;
Neuroprotection by the endogenous cannabinoid anandamide and arvanil against in vivo excitotoxicity in the rat: role of vanilloid receptors and lipoxygenases: W.B. Veldhuis, et al.; J. Neurosci. 23, 4127 (2003), Abstract;
Endogenous cardiac glycosides, a new class of steroid hormones: W. Schoner; Eur. J. Biochem. 269, 2440 (2002), Abstract;
The cardiac sodium pump: structure and function: A.A. McDonnough, et al.; Basic Res. Cardiol. 97 Suppl1, I19 (2002), Abstract;
Digitalis and digitalislike compounds down-regulate gene expression of the intracellular signaling protein 14-3-3 in rat lens: D. Lichtstein, et al.; Hypertens. Res. 23 Suppl., S51 (2000), Abstract;
Allosteric regulation of the access channels to the Rb+ occlusion sites of (Na+ + K+)-ATPase: J. Hasenauer, et al.; J. Biol. Chem. 268, 3289 (1993), Abstract; Full Text
Charge movement by the Na/K pump in Xenopus oocytes: R.F. Rakowski; J. Gen. Physiol. 101, 117 (1993), Abstract;
Resting membrane potential and potassium currents in cultured parasympathetic neurones from rat intracardiac ganglia: Z.J. Xu & D.J. Adams; J. Physiol. 456, 405 (1992), Abstract;
Subchronic methamphetamine treatment enhances ouabain-induced striatal dopamine efflux in vivo: A. Kanzaki, et al.; Brain Res. 569, 181 (1992), Abstract;
Actions of bufalin and cinobufotalin, two bufadienolides respectively more active and less active than ouabain, on ouabain binding and 86Rb uptake by human erythrocytes: A.A. Brownlee, et al.; Clin. Sci. (Lond.) 78, 169 (1990), Abstract;
Subacute noradrenergic agonist infusions in vivo increase Na+, K+- ATPase and ouabain binding in rat cerebral cortex: A.C. Swann & J.D. Steketee; J. Neurochem. 52, 1598 (1989), Abstract;

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