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Ganglioside GD3 . disodium salt (bovine buttermilk)

ALX-302-010-MC05 0.5 mg 239.00 USD
ALX-302-010-M001 1 mg 413.00 USD
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Induces mitochondrial permeability transition (MPT) without requiring elevated Ca2+ levels and thus triggers Fas-mediated apoptosis.

Product Details

Alternative Name:Disialoganglioside GD3 . 2Na (bovine buttermilk), GD3 . 2Na (bovine buttermilk)
Sequence:[Il3(Neu5Ac)2LacCer] [[α-Neu5Ac-(2→8)-α-Neu5Ac-(2→3)]-β-Gal-(1→4)-β-Glc-(1→1')-Cer]
Formula:C70H123N3O29 . 2Na
MW:1470.8 . 46.0 (calculated on sphingosine C18:1 and stearic acid)
Source:Bovine buttermilk
Purity:≥98% (TLC)
Solubility:Soluble in chloroform/methanol, 2:1
Shipping:Ambient Temperature
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only
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Product Literature References

Involvement of ganglioside GT1b in glutamate release from neuroblastoma cells: S. Watanabe, et al.; Neurosci. Lett. 517, 140 (2012), Abstract;
Ganglioside GD3 and its mimetics induce cytochrome c release from mitochondria: Y. Inoki, et al.; BBRC 276, 1210 (2000), Abstract;
Apoptogenic ganglioside GD3 directly induces the mitochondrial permeability transition: B.S. Kristal & A.M. Brown; J. Biol. Chem. 274, 23169 (1999), Abstract; Full Text
Ganglioside GD3, the mitochondrial permeability transition, and apoptosis: B.S. Kristal & A.M. Brown; Ann. NY Acad. Sci. 893, 321 (1999), (Review), Abstract;
Lipid signaling in CD95-mediated apoptosis: F. Malisan & R. Testi; FEBS Lett 452, 100 (1999), (Review), Abstract;

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