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AMI-1

PRMT inhibitor
 
ALX-270-440-M005 5 mg 113.00 USD
 
ALX-270-440-M025 25 mg 467.00 USD
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Potent, cell permeable and specific inhibitor of protein arginine N-methyltransferases (PRMTs) (IC50=8.8µM for human PRMT1 and 3.0µM for yeast Hmt1p). Does not compete for the AdoMet (S-adenosyl-L-methionine; SAM) binding site. Exhibits only minimal effects on lysine N-methyltransferases. Suppresses the transcriptional coactivator activity of PRMT1 and PRMT4. Inhibitor of HIV-1 RT polymerase (IC50=5.0µM).

Product Specification

Formula:C21H12N2O9S2Na4
 
MW:592.4
 
CAS:20324-87-2
 
Purity:≥98% (HPLC)
 
Identity:Determined by NMR.
 
Appearance:Brown solid.
 
Solubility:Soluble in water, 100% ethanol or DMSO.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Handling:Protect from light. Hygroscopic. After reconstitution, prepare aliquots and store at -20°C.
 
Regulatory Status:RUO - Research Use Only
 
270-440
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Product Literature References

Small molecule regulators of protein arginine methyltransferases: D. Cheng, et al.; J. Biol. Chem. 279, 23892 (2004), Abstract; Full Text
A novel mechanism for inhibition of HIV-1 reverse transcriptase: A.G. Skillman, et al.; Bioorg. Chem. 30, 443 (2002), Abstract;

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