A cell permeable, selective, and ATP-competitive inhibitor of Rho kinase (ROCK) activity (IC50=25µM). Does not inhibit the activation of Rho nor does it affect the in vitro activities of MLCK, PKCα, and SAPK2a/p38α. Shown to be less potent than Y-27632 (Prod. No. ALX-270-333).
Product Details
| Formula: | C13H10N2 |
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| MW: | 194.2 |
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| CAS: | 7272-84-6 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Determined by NMR. |
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| Appearance: | Off-white to beige solid. |
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| Solubility: | Soluble in DMSO or dimethyl formamide. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stock solutions are stable for up to 6 months when stored at -20°C. |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Scratch n’ screen for inhibitors of cell migration: J. Soderholm & R. Heald; Chem. Biol.
12, 263 (2005),
Abstract;
Screening for cell migration inhibitors via automated microscopy reveals a Rho-kinase inhibitor: J.C. Yarrow, et al.; Chem. Biol.
12, 385 (2005),
Abstract;
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