Inhibitor of histone deacetylase 1 (HDAC1) (IC50 = 4.5µM) and maize histone deacetylase HD2 (IC50=1.9µM).
Product Details
| Alternative Name: | 3-(4-Toluoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide |
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| Formula: | C16H16N2O3 |
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| MW: | 284.3 |
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| Purity: | ≥97% (HPLC) |
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| Identity: | Determined by 1H-NMR. |
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| Appearance: | Off-white powder. |
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| Solubility: | Soluble in DMSO. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Binding mode analysis of 3-(4-benzoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide: a new synthetic histone deacetylase inhibitor inducing histone hyperacetylation, growth inhibition, and terminal cell differentiation: A. Mai, et al.; J. Med. Chem.
45, 1778 (2002),
Abstract;
3-(4-aroyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides, a new class of synthetic histone deacetylase inhibitors: S. Massa, et al.; J. Med. Chem.
44, 2069 (2001),
Abstract;
