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MC 1293

HDAC1 inhibitor
ALX-270-344-M005 5 mg 202.00 USD
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Inhibitor of histone deacetylase 1 (HDAC1) (IC50 = 4.5µM) and maize histone deacetylase HD2 (IC50=1.9µM).

Product Specification

Alternative Name:3-(4-Toluoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide
Purity:≥97% (HPLC)
Identity:Determined by 1H-NMR.
Appearance:Off-white powder.
Solubility:Soluble in DMSO.
Long Term Storage:-20°C
Handling:Protect from light.
ALX-270-344 structure
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ALX-270-344 structure

Product Literature References

Binding mode analysis of 3-(4-benzoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide: a new synthetic histone deacetylase inhibitor inducing histone hyperacetylation, growth inhibition, and terminal cell differentiation: A. Mai, et al.; J. Med. Chem. 45, 1778 (2002), Abstract;
3-(4-aroyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides, a new class of synthetic histone deacetylase inhibitors: S. Massa, et al.; J. Med. Chem. 44, 2069 (2001), Abstract;

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