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PARP-1 inhibitor
ALX-270-221-M001 1 mg 77.00 USD
ALX-270-221-M005 5 mg 309.00 USD
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Very potent poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor.

Product Details

Purity:≥98% (HPLC)
Identity:Determined by 1H-NMR.
Appearance:Off-white to light brown solid.
Solubility:Soluble in DMSO; slightly soluble in 100% ethanol; insoluble in water.
Shipping:Ambient Temperature
Long Term Storage:+4°C
Use/Stability:Stock solutions in DMSO are stable for up to 1 month when stored at -20°C.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Autophagy requires poly(adp-ribosyl)ation-dependent AMPK nuclear export: J.M. Rodríguez-Vargas, et al.; Cell Death Differ. 23, 2007 (2016), Application(s): Cell treatment, MCF7 GFP-LC3 cells, Abstract;
Differential roles of RIPK1 and RIPK3 in TNF-induced necroptosis and chemotherapeutic agent-induced cell death: K. Moriwaki, et al.; Cell Death Dis. 6, e1636 (2015), Application(s): Cell Culture, Abstract; Full Text
Inhibition of poly(ADP-ribose) polymerase-1 or poly(ADP-ribose) glycohydrolase individually, but not in combination, leads to improved chemotherapeutic efficacy in HeLa cells: X. Feng, et al.; Int. J. Onc. 42, 749 (2013), Abstract; Full Text
Comet assay as a novel approach for studying DNA damage in focal cerebral ischemia: differential effects of NMDA receptor antagonists and poly(ADP-ribose) polymerase inhibitors: L. Giovannelli, et al.; J. Cereb. Blood Flow Metab. 22, 697 (2002), Abstract;
Poly(ADP-ribose) polymerase inhibitors attenuate necrotic but not apoptotic neuronal death in experimental models of cerebral ischemia: F. Moroni, et al.; Cell Death Differ. 8, 921 (2001), Abstract;
Post-treatment with an inhibitor of poly(ADP)-ribose polymerase attenuates cerebral damage in focal ischemia: K. Takahashi, et al.; Brain Res. 829, 46 (1999), Abstract; Full Text
Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion: C. Szabo & V.L. Dawson; TIPS 19, 287 (1998), (Review), Abstract;
Neuroprotective effects of inhibiting poly(ADP-ribose) synthetase on focal cerebral ischemia in rats: H. Takahashi, et al.; J. Cereb. Blood Flow Metab. 17, 1137 (1997), Abstract;
Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia: M.J.L. Eliasson, et al.; Nat. Med. 3, 1089 (1997), Abstract;
Dihydroisoquinolines: the design and synthesis of a new series of potent inhibitors of poly(ADP-ribose) polymerase: M.J. Suto, et al.; Anticancer Drug Des. 6, 107 (1991), Abstract;

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The PARP Family & ADP Ribosylation
The PARP Family & ADP Ribosylation
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