Replaces Prod. #: BML-EI277
Potent and selective inhibitor of EGFR (IC50 = 3nM). Reduces EGF-stimulated DNA synthesis in Rat-1 fibroblasts by ~75% at 0.25μM. Blocks EGF-dependent src-family kinase activation and p21/Cip 1/WAF1 induction in A431 cells. Also inhibits H2O2-induced stimulation of amphiregulin expression in rat gastric epithelium (RGM 1) cells.
Product Details
| Alternative Name: | 4-(3-Chloroanilino)-6,7-dimethoxyquinazoline |
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| Formula: | C16H14ClN3O2 |
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| MW: | 315.8 |
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| CAS: | 153436-53-4 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to light yellow solid. |
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| Solubility: | Soluble in DMSO (10mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. Packaged under inert gas. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Application(s): Cell Culture,
Abstract;
Full Text
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Abstract;
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