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Caspase and granzyme inhibitor
ALX-260-073-M001 1 mg 332.00 USD
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Irreversible, cell permeable inhibitor of caspase-8 and granzyme B. Inhibits also caspase-10.

Product Details

Alternative Name:Caspase-8 inhibitor (fluoromethylketone), Granzyme B inhibitor (fluoromethylketone)
Purity:≥95% (TLC)
Appearance:White to off-white solid.
Solubility:Soluble in DMSO.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Use/Stability:Store stock solutions in aliquots at -20°C.
Handling:Packaged under inert gas.
Technical Info/Product Notes:We recommend a final concentration of 2µM for inhibiting caspase activity in Jurkat cell culture. The optimal doses may vary for different cells and culture conditions.
Regulatory Status:RUO - Research Use Only

Product Literature References

Clostridioides difficile toxin B alone and with pro-inflammatory cytokines induces apoptosis in enteric glial cells by activating three different signalling pathways mediated by caspases, calpains and cathepsin B: K. Fettucciari, et al.; Cell. Mol. Life Sci. 79, 442 (2022), Abstract;
Reconstitution of caspase-8 sensitizes JB6 cells to TRAIL: I.K. Kim, et al.; BBRC 277, 311 (2000), Abstract;
Caspase-mediated proteolysis and activation of protein kinase Cδ plays a central role in neutrophil apoptosis: A. Khwaja & L. Tatton; Blood 94, 291 (1999), Abstract; Full Text
Inhibition of sphingolipid induced apoptosis by caspase inhibitors indicates that sphingosine acts in an earlier part of the apoptotic pathway than ceramide: E.A. Sweeney, et al.; FEBS Lett. 425, 61 (1998), Abstract;
Membrane oligomerization and cleavage activates the caspase-8 (FLICE/MACHalpha1) death signal: D.A. Martin, et al.; J. Biol. Chem. 273, 4345 (1998), Abstract; Full Text
Role of caspases in immunotoxin-induced apoptosis of cancer cells: A. Keppler-Hafkemeyer, et al.; Biochemistry 37, 16934 (1998), Abstract;