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Caspase inhibitor
ALX-260-071-M001 1 mg 282.00 USD
ALX-260-071-M005 5 mg 1,137.00 USD
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Irreversible, cell permeable broad-spectrum caspase inhibitor.

Product Specification

Alternative Name:Caspase family inhibitor (fluoromethylketone)
Purity:≥95% (TLC)
Appearance:White to off-white powder.
Solubility:Soluble in DMSO or dimethyl formamide.
Long Term Storage:-20°C
Use/Stability:Stock solutions should be divided into aliquots and stored at -20°C. For long term storage keep aliquots at -70°C.
Handling:Keep cool and dry. After reconstitution, prepare aliquots and store at -80°C.
Technical Info/Product Notes:The carboxyl groups are OMe ester form to enhance cell permeability. If purified enzyme is used, esterase should be added for the hydrolysis of the ester groups.
Protocol:Prepare a 20 mM stock solution of the caspase inhibitor in DMSO. Add 1 µl of above stock solutions to 1 ml of culture medium containing cells to give 20 mM final concentration. DMSO concentration above of 0.2 % may cause cellular toxicity thus masking the effect of the ICE-protease inhibitor Boc-D(OMe)-FMK. For in vivo experiments extending for 12 to 48 hours, fresh inhibitor may have to be added (injected) due to inactivation by reaction with cysteine protease.

Product Literature References

Mechanisms of cell death induced by arginase and asparaginase in precursor B-cell lymphoblasts: L.E. Metayer, et al.; Apoptosis 24, 145 (2019), Abstract; Full Text
The neuroprotective effect of pituitary adenylate cyclase-activating polypeptide on cerebellar granule cells is mediated through inhibition of the CED3-related cysteine protease caspase-3/CPP32: D. Vaudry, et. al.; PNAS 97, 13390 (2000), Abstract; Full Text
A DEVD-inhibited caspase other than CPP32 is involved in the commitment of cerebellar granule neurons to apoptosis induced by K+ deprivation: S.R. D'Mello, et al.; J. Neurochem. 70, 1809 (1998), Abstract;
Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury: Y. Cheng, et al.; J. Clin. Invest. 101, 1992 (1998), Abstract; Full Text
Caspase inhibitor BD-fmk distinguishes transforming growth factor β-induced apoptosis from growth inhibition: T.L. Brown, et al.; Cell Growth Differ. 9, 869 (1998), Abstract;
Different interleukin-1 beta converting enzyme (ICE) family protease requirements for the apoptotic death of T lymphocytes triggered by diverse stimuli: A. Sarin, et al.; J. Exp. Med. 184, 2445 (1996), Abstract;

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