Replaces Prod. #: BML-P403
Potent and reversible inhibitor of caspase-1. Also inhibits caspase-4. Strongly inhibits anti-Fas induced apoptosis in L929-Fas cells.
Product Details
| Alternative Name: | Caspase-1 inhibitor (aldehyde) |
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| Sequence: | Ac-Tyr-Val-Ala-Asp-CHO |
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| Formula: | C23H32N4O8 |
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| MW: | 492.5 |
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| Formulation: | Lyophilized. |
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| Peptide Content: | 70-90% |
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| Purity: | ≥96% (HPLC) |
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| Appearance: | White powder. |
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| Solubility: | Soluble in DMSO or water (both 50mg/ml). |
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| Reconstitution: | Add 0.2ml DMSO per 1.0mg peptide. Shake well until all the contents are dissolved. This furnishes a 10mM solution of this material. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stock solutions should be divided into aliquots and stored at -20°C. |
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| Handling: | Keep under inert gas. Keep cool and dry. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Omega-3 docosahexaenoic acid induces pyroptosis cell death in triple-negative breast cancer cells: N. Pizato, et al.; Sci. Rep.
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Interferon gamma induces upregulation and activation of caspases 1, 3, and 8 to produce apoptosis in human erythroid progenitor cells: C. Dai & S.B. Krantz; Blood
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Abstract;
Inhibition of human caspases by peptide-based and macromolecular inhibitors: M. Garcia-Calvo, et al.; J. Biol. Chem.
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Full Text
Role of the nuclear localization sequence in fibroblast growth factor-1-stimulated mitogenic pathways: Y.Z. Lin, et al.; J. Biol. Chem.
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Full Text
Sequential activation of ICE-like and CPP32-like proteases during Fas- mediated apoptosis: M. Enari, et al.; Nature
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Abstract;
Peptide inhibitors of the ICE protease family arrest programmed cell death of motoneurons in vivo and in vitro: C.E. Milligan, et al.; Neuron
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Abstract;
Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis: M. Los, et al.; Nature
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Abstract;
Crystal structure of the cysteine protease interleukin-1 beta- converting enzyme: a (p20/p10)2 homodimer: N.P.C. Walker, et al.; Cell
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Abstract;
Inactivation of interleukin-1 beta converting enzyme by peptide (acyloxy)methyl ketones: N.A. Thornberry, et al.; Biochemistry
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Abstract;
Interleukin-1 beta converting enzyme: N.A. Thornberry; Methods Enzymol.
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Abstract;
Structure and mechanism of interleukin-1 β converting enzyme: K.P. Wilson, et al.; Nature
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Abstract;
Interleukin 1 β (IL-1 β) processing in murine macrophages requires a structurally conserved homologue of human IL-1 β converting enzyme: S.M. Molineaux, et al.; PNAS
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Abstract;
A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes: N.A. Thornberry, et al.; Nature
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Abstract;
Synthesis of a potent, reversible inhibitor of interleukin-1β converting enzyme: K.T. Chapman; Bioorg. Med. Chem. Lett. 2, 613 (1992),
