Replaces Prod. #: BML-P403
Potent and reversible inhibitor of caspase-1. Also inhibits caspase-4. Strongly inhibits anti-Fas induced apoptosis in L929-Fas cells.
Product Details
Alternative Name: | Caspase-1 inhibitor (aldehyde) |
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Sequence: | Ac-Tyr-Val-Ala-Asp-CHO |
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Formula: | C23H32N4O8 |
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MW: | 492.5 |
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Formulation: | Lyophilized. |
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Peptide Content: | 70-90% |
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Purity: | ≥96% (HPLC) |
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Appearance: | White powder. |
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Solubility: | Soluble in DMSO or water (both 50mg/ml). |
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Reconstitution: | Add 0.2ml DMSO per 1.0mg peptide. Shake well until all the contents are dissolved. This furnishes a 10mM solution of this material. |
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Shipping: | Ambient |
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Long Term Storage: | -20°C |
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Use/Stability: | Stock solutions should be divided into aliquots and stored at -20°C. |
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Handling: | Keep under inert gas. Keep cool and dry. |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Role of the nuclear localization sequence in fibroblast growth factor-1-stimulated mitogenic pathways: Y.Z. Lin, et al.; J. Biol. Chem.
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Sequential activation of ICE-like and CPP32-like proteases during Fas- mediated apoptosis: M. Enari, et al.; Nature
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Peptide inhibitors of the ICE protease family arrest programmed cell death of motoneurons in vivo and in vitro: C.E. Milligan, et al.; Neuron
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Inactivation of interleukin-1 beta converting enzyme by peptide (acyloxy)methyl ketones: N.A. Thornberry, et al.; Biochemistry
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Abstract;
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