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Inhibitor of caspase-1 and -4
ALX-260-027-M001 1 mg 82.00 USD
ALX-260-027-M005 5 mg 263.00 USD
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Replaces Prod. #: BML-P403

Potent and reversible inhibitor of caspase-1. Also inhibits caspase-4. Strongly inhibits anti-Fas induced apoptosis in L929-Fas cells.

Product Details

Alternative Name:Caspase-1 inhibitor (aldehyde)
Peptide Content:70-90%
Purity:≥96% (HPLC)
Appearance:White powder.
Solubility:Soluble in DMSO or water (both 50mg/ml).
Reconstitution:Add 0.2ml DMSO per 1.0mg peptide. Shake well until all the contents are dissolved. This furnishes a 10mM solution of this material.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Use/Stability:Stock solutions should be divided into aliquots and stored at -20°C.
Handling:Keep under inert gas. Keep cool and dry.
Regulatory Status:RUO - Research Use Only

Product Literature References

Activation of NLRP3 by uropathogenic Escherichia coli is associated with IL-1β release and regulation of antimicrobial properties in human neutrophils: I. Demirel, et al.; Sci. Rep. 10, 21837 (2020), Abstract; Full Text
Gasdermin D plays a vital role in the generation of neutrophil extracellular traps: G. Sollberger, et al.; Sci. Immunol. 3, eaar6689 (2018), Abstract;
Omega-3 docosahexaenoic acid induces pyroptosis cell death in triple-negative breast cancer cells: N. Pizato, et al.; Sci. Rep. 8, 1952 (2018), Abstract;
Interferon gamma induces upregulation and activation of caspases 1, 3, and 8 to produce apoptosis in human erythroid progenitor cells: C. Dai & S.B. Krantz; Blood 93, 3309 (1999), Abstract;
Inhibition of human caspases by peptide-based and macromolecular inhibitors: M. Garcia-Calvo, et al.; J. Biol. Chem. 273, 32608 (1998), Abstract; Full Text
Role of the nuclear localization sequence in fibroblast growth factor-1-stimulated mitogenic pathways: Y.Z. Lin, et al.; J. Biol. Chem. 271, 3505 (1996), Abstract; Full Text
Sequential activation of ICE-like and CPP32-like proteases during Fas- mediated apoptosis: M. Enari, et al.; Nature 380, 723 (1996), Abstract;
Peptide inhibitors of the ICE protease family arrest programmed cell death of motoneurons in vivo and in vitro: C.E. Milligan, et al.; Neuron 15, 385 (1995), Abstract;
Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis: M. Los, et al.; Nature 375, 81 (1995), Abstract;
Crystal structure of the cysteine protease interleukin-1 beta- converting enzyme: a (p20/p10)2 homodimer: N.P.C. Walker, et al.; Cell 78, 343 (1994), Abstract;
Inactivation of interleukin-1 beta converting enzyme by peptide (acyloxy)methyl ketones: N.A. Thornberry, et al.; Biochemistry 33, 3934 (1994), Abstract;
Interleukin-1 beta converting enzyme: N.A. Thornberry; Methods Enzymol. 244, 615 (1994), Abstract;
Structure and mechanism of interleukin-1 β converting enzyme: K.P. Wilson, et al.; Nature 370, 270 (1994), Abstract;
Interleukin 1 β (IL-1 β) processing in murine macrophages requires a structurally conserved homologue of human IL-1 β converting enzyme: S.M. Molineaux, et al.; PNAS 90, 1809 (1993), Abstract;
A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes: N.A. Thornberry, et al.; Nature 356, 768 (1992), Abstract;
Synthesis of a potent, reversible inhibitor of interleukin-1β converting enzyme: K.T. Chapman; Bioorg. Med. Chem. Lett. 2, 613 (1992),