| ALX-210-915-C050 | 50 µg | 283.00 USD |  |
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| Alternative Name: | CRADD, Caspase and RIP adaptor with death domain, RIP-associated protein with a death domain |
| Host: | Rabbit |
| Immunogen: | Recombinant human RAIDD (aa 1-199). |
| UniProt ID: | P78560 |
| Source: | Purified from rabbit serum. |
| Species reactivity: | Human |
| Applications: | IP, WB |
| Recommended Dilutions/Conditions: | Western Blot (1:1,000) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Purity Detail: | Affinity purified. |
| Formulation: | Liquid. In PBS containing 0.02% sodium azide. |
| Handling: | Avoid freeze/thaw cycles. |
| Shipping: | Blue Ice |
| Short Term Storage: | +4°C |
| Long Term Storage: | -20°C |
| Scientific Background: | RAIDD (RIP-associated ICH-1 homologous protein with a death domain) is an adaptor molecule that mediates the action of cysteine proteases involved in apoptosis. In human cell lines, the caspase-2 adaptor RAIDD interacts selectively with caspase-2 through its caspase recruitment domain (CARD) and leads to caspase-2-dependent death. RAIDD overexpression induced caspase-2, CARD- and caspase-9-dependent apoptosis of PC12 cells and sympathetic neurons. Apoptosis correlated with the formation of discrete perinuclear aggregates. Both death and aggregates required the expression of full-length RAIDD. It has been reported that activation of caspase-2 occurs in a complex that contains the death domain–containing protein PIDD, whose expression is induced by p53, and the adaptor protein RAIDD. |
| Regulatory Status: | RUO - Research Use Only |
