| ALX-210-537-R100 | 100 µl | 397.00 USD |  |
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| Alternative Name: | Vitronectin receptor α subunit, αV integrin |
| Host: | Rabbit |
| Immunogen: | Synthetic peptide corresponding to C-terminal portion of human CD51 (αV integrin) (aa 1021-1034) (cytoplasmic domain). |
| UniProt ID: | P06756 |
| Species reactivity: | Species independent |
| Specificity: | Recognizes the cytoplasmic domain of CD51. |
| Applications: | ELISA, ICC, IHC (FS), IHC (PS), IP, WB |
| Recommended Dilutions/Conditions: | Immunocytochemistry (1:1,000) Immunohistochemistry (frozen sections, 1:500) Immunohistochemistry (paraffin sections, 1:500) Immunoprecipitation (5µl per 5x106 cells) Western Blot (1:5,000) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Formulation: | Liquid. Neat serum containing 0.05% sodium azide. |
| Handling: | Avoid freeze/thaw cycles. |
| Shipping: | Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | CD51 (integrin αV subunit) associates with CD61 (integrin β3 subunit) binding to the RGD sequence in extracellular matrix proteins like vitronectin, fibrinogen, thrombospondin, von Willebrand factor and osteopontin. The αV/β3 heterodimer is expressed in endothelial cells, leukocytes, NK cells, macrophages, neutrophils, platelets and several malignant tumor cells and seems to play a role in embryo implantation, angiogenesis, wound healing and cancer. αV/β3 is also highly expressed in osteoclasts being important for bone resorption. |
| Regulatory Status: | RUO - Research Use Only |
