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Big Endothelin-1 (human) (1-38)

Endothelin-converting enzyme substrate
ALX-152-001-PC01 0.1 mg* 147.00 USD
ALX-152-001-PC05 0.5 mg* 671.00 USD
ALX-152-001-P001 1 mg* 1,072.00 USD
Do you need bulk/larger quantities?
Biological precursor of endothelin 1. Cleaved to yield endothelin-1 via the activity of the endothelin-converting enzyme (ECE). Endothelins are endothelium-derived vasoconstrictor peptides.

Product Details

Alternative Name:Big ET-1 (1-38)
(Disulfide bonds between Cys1-Cys15and Cys3-Cys11)
Quantity:*Sold as net peptide weight.
Purity:≥98% (HPLC)
Appearance:White to off-white powder.
Solubility:1mg/ml soluble in water; also soluble in 0.5% acetic acid.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only

Product Literature References

Putative precursors of endothelin have less vasoconstrictor activity in vitro but a potent pressor effect in vivo: T. Kashiwabara, et al.; FEBS Lett. 247, 73 (1989), Abstract;
Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin: Y. Itoh, et al.; FEBS Lett. 231, 440 (1988), Abstract;