Biological precursor of endothelin 1. Cleaved to yield endothelin-1 via the activity of the endothelin-converting enzyme (ECE). Endothelins are endothelium-derived vasoconstrictor peptides.
Product Details
| Alternative Name: | Big ET-1 (1-38) |
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| Sequence: | H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Arg-Ser-OH
(Disulfide bonds between Cys1-Cys15and Cys3-Cys11) |
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| Formula: | C189H282N48O56S5 |
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| MW: | 4283.0 |
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| CAS: | 121014-53-7 |
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| Quantity: | *Sold as net peptide weight. |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to off-white powder. |
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| Solubility: | 1mg/ml soluble in water; also soluble in 0.5% acetic acid. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Putative precursors of endothelin have less vasoconstrictor activity in vitro but a potent pressor effect in vivo: T. Kashiwabara, et al.; FEBS Lett.
247, 73 (1989),
Abstract;
Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin: Y. Itoh, et al.; FEBS Lett.
231, 440 (1988),
Abstract;
