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ALX-105-005-G005 5 g 40.00 USD
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Derivative of cysteine wherein an acetyl group is attached to the amino group. Is used as a specific antidote in cases of acetaminophen overdose.

Product Details

Alternative Name:LNAL, N-Acetyl-3-mercaptoalanine, L-α-Acetamido-β-mercaptopropionic acid, NAC
MI:14: 88
Purity:≥98% (TLC)
Appearance:White powder.
Solubility:Soluble in 5M hydrochloric acid (hot) (100mg/ml), methanol (50mg/ml), water or 100% ethanol; insoluble in chloroform or ether.
Long Term Storage:+4°C
Regulatory Status:RUO - Research Use Only
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Product Literature References

Carbon Monoxide Releasing Molecule-3 Enhances Heme Oxygenase-1 Induction via ROS-Dependent FoxO1 and Nrf2 in Brain Astrocytes: C. C. Lin, et al.; Oxid. Med. Cell. Longev. 2021, 5521196 (2021), Abstract;
Heme oxygenase-1 mediates BAY 11-7085 induced ferroptosis: L.C. Chang, et al.; Cancer Lett. 416, 124 (2018), Abstract;
Novel β-phenylacrylic acid derivatives exert anti-cancer activity by inducing Src-mediated apoptosis in wild-type KRAS colon cancer: S.J. Kim, et al.; Cell Death Dis. 9, 877 (2018), Abstract; Full Text
Autophagy-induced KDR/VEGFR-2 activation promotes the formation of vasculogenic mimicry by glioma stem cells: HB. Wu, et al.; Autophagy 13, 1528 (2017), Abstract; Full Text
Eupafolin nanoparticles protect HaCaT keratinocytes from particulate matter-induced inflammation and oxidative stress: Z.C. Lin, et al.; Int. J. Nanomedicine 11, 3907 (2016), Application(s): Assessing MAPK signalling pathways and cellular responses to proliferation, apoptosis, differentiation, and inflammation in humans, Abstract; Full Text
High Uric Acid Activates the ROS-AMPK Pathway, Impairs CD68 Expression and Inhibits OxLDL-Induced Foam-Cell Formation in a Human Monocytic Cell Line, THP-1: C. Luo, et al.; Cell. Physiol. Biochem. 40, 538 (2016), Abstract;
High Uric Acid Induces Insulin Resistance in Cardiomyocytes In Vitro and In Vivo: L. Zhi, et al.; PLoS One. 11, e0147737 (2016), Application(s): Cell culture, Abstract; Full Text
Reactive oxygen species-mediated synergistic and preferential induction of cell death and reduction of clonogenic resistance in breast cancer cells by combined cisplatin and FK228: L.A. Pluchino, et al.; Cancer Lett. 381, 124 (2016), Application(s): Cell culture; blockage of ROS, Abstract;
Areca nut exposure increases secretion of tumor‐promoting cytokines in gingival fibroblasts that trigger DNA damage in oral keratinocytes: R.P. Illeperuma, et al.; Int. J. Cancer 137, 2545 (2015), Application(s): Cell Culture, Abstract; Full Text
Pyrrolidine dithiocarbamate inhibits TNF-alpha-dependent activation of NF-kappaB by increasing intracellular copper level in human aortic smooth muscle cells: A. Iseki, et al.; Biochem. Biophys. Res. Commun. 276, 88 (2000), Abstract;
Suppression of NF-kappaB activation and cytokine production by N- acetylcysteine in pancreatic acinar cells: H. Kim, et al.; Free Radic. Biol. Med. 29, 674 (2000), Abstract;
Supplementation of N-acetylcysteine inhibits NFkappaB activation and protects against alloxan-induced diabetes in CD-1 mice: E. Ho, et al.; FASEB J. 13, 1845 (1999), Abstract;
Induction of apoptosis by pyrrolidinedithiocarbamate and N- acetylcysteine in vascular smooth muscle cells: J.C. Tsai, et al.; J. Biol. Chem. 271, 3667 (1996), Abstract; Full Text
Distinct effects of thioredoxin and antioxidants on the activation of transcription factors NF-kappa B and AP-1: H. Schenk, et al.; PNAS 91, 1672 (1994), Abstract;
Conversion of glyceryl trinitrate to nitric oxide in tolerant and non- tolerant smooth muscle and endothelial cells: D. Salvemini, et al.; Br. J. Pharmacol. 108, 162 (1993), Abstract;
Modulation of platelet function by free radicals and free-radical scavengers: D. Salvemini & R. Botting; TIPS 14, 36 (1993), (Review), Abstract;

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