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HOP monoclonal antibody (DS14F5)

ADI-SRA-1500-D 50 µg 249.00 USD
ADI-SRA-1500-F 200 µg 500.00 USD
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Product Details

Alternative Name:STIP1, STI1, STUB1, p60, CHIP
Immunogen:Chicken HOP (p60).
UniProt ID:P31948
Source:Purified from mouse ascites.
Species reactivity:Human, Mouse, Rat
Bovine, Chicken, Dog, Guinea pig, Hamster, Mink, Monkey, Porcine, Rabbit, Sheep, Xenopus
Applications:IHC, IP, WB
Recommended Dilutions/Conditions:Western Blot (1:1,000, colorimetric)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects a band of ~60kDa by Western blot.
Purity Detail:Protein G affinity purified.
Formulation:Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
Handling:Avoid freeze/thaw cycles.
Shipping:Blue Ice
Long Term Storage:-20°C
Scientific Background:Hsp70-Hsp90 Organizing Protein (HOP, p60) is an ~60kDa protein that is a critical intermediate component for the efficient maturation of steroid receptor complexes, serving to recruit Hsp90 to Hsp70-containing complexes. HOP contains three tetratricopeptide repeat (TPR) domains, TPR1, TPR2a, and TPR2b.
Technical Info/Product Notes:Recommended by the Human Protein Atlas Organization for IHC (Ensembl No. ENSG00000168439).
Regulatory Status:RUO - Research Use Only

Product Literature References

Phosphorylation of the Hsp90 Co-Chaperone Hop Changes its Conformational Dynamics and Biological Function: M. Castelli, et al.; J. Mol. Biol. 435, 167931 (2023), Abstract;
Evodiamine inhibits both stem cell and non-stem-cell populations in human cancer cells by targeting heat shock protein 70: S.Y. Hyun, et al.; Theranostics 11, 2932 (2021), Application(s): Western Blot, Abstract; Full Text
The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma: M. Heider, et al.; Mol. Cell 81, 1170 (2021), Abstract;
Heat shock protein 90 associates with Toll-like receptors 7/9 and mediates self-nucleic acid recognition in SLE: K. Saito, et al.; Eur. J. Immunol. 45, 2028 (2015), Abstract; Full Text
Psoriasis-associated variant Act1 D10N with impaired regulation by Hsp90: C. Wang, et al.; Nat. Immunol. 14, 72 (2013), Application(s): WB using MEF extracts, Abstract; Full Text
Hsp90 charged-linker truncation reverses the functional consequences of weakened hydrophobic contacts in the N domain: S. Tsutsumi, et al. ; Nat. Struct. Mol. Biol. 16, 1141 (2009), Application(s): WB, IP using mouse cell lysates, Abstract;
Novel oxime derivatives of radicicol induce erythroid differentiation associated with preferential G(1) phase accumulation against chronic myelogenous leukemia cells through destabilization of Bcr-Abl with Hsp90 complex: Y. Shiotsu, et al.; Blood 96, 2284 (2000), Application(s): WB using human samples, Abstract;
Quantitative assessment of complex formation of nuclear-receptor accessory proteins: A. Jungbauer, et al. ; Biochem. J. 345, 627 (2000), Application(s): WB using human samples, Abstract;
Mutation of Hip's carboxy-terminal region inhibits a transitional stage of progesterone receptor assembly: D.F. Smith, et al. ; Mol. Cell. Biol. 18, 944 (1998), Application(s): IP using rabbit samples, Abstract;
The role of DnaJ-like proteins in glucocorticoid receptor.hsp90 heterocomplex assembly by the reconstituted hsp90.p60.hsp70 foldosome complex: W.B. Pratt, et al. ; J. Biol. Chem. 273, 7358 (1998), Application(s): IP using rabbit samples, Abstract;
Proteins interacting with the molecular chaperone hsp70/hsc70: physical associations and effects on refolding activity: U. Gehring, et al. ; FEBS Lett. 417, 109 (1997), Application(s): WB using human samples, Abstract;

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