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HSP90β monoclonal antibody (K3701)

ADI-SPA-843-D 50 µg 250.00 USD
ADI-SPA-843-F 200 µg 553.00 USD
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Product Details

Alternative Name:HSP84, Heat shock protein 90β
Immunogen:Recombinant human HSP90β.
UniProt ID:P08238
Source:Purified from hybridoma tissue culture supernatant.
Species reactivity:Human, Mouse, Rat
Bovine, Dog, Guinea pig, Hamster, Porcine, Rabbit, Sheep
Applications:Flow Cytometry, WB
Recommended Dilutions/Conditions:Flow Cytometry (10µg/ml)
Western Blot (1:1,000, colorimetric)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects a band of ~90kDa by Western blot.
Purity Detail:Ammonium sulfate precipitation purified.
Formulation:Liquid. In saline, pH 6.9, containing 0.1% sodium azide.
Handling:Avoid freeze/thaw cycles.
Shipping:Blue Ice
Long Term Storage:-20°C
Scientific Background:The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress, and includes cytoplasmic (Hsp90-alpha/beta), ER (grp94), and mitochondrial (TRAP1) localized members. Structurally, Hsp90 is characterized by an N-terminal ATP-binding domain, a medial substrate-binding domain, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones (e.g. Hsp40, Hsp70, Hop, p23) to stabilize a multitude of client protein substrates, including steroid hormone receptors, protein kinases, and transcription factors. The essential binding and hydrolysis of ATP by Hsp90 is inhibited by ansamycin drugs (e.g. geldanamycin, 17-AAG) which occupy the N-terminal Hsp90 nucleotide-binding pocket. Many Hsp90 client proteins such as erbB2/Her-2, c-raf, bcr-abl, p53, and hTERT, are members of well characterized oncogenic pathways, making Hsp90 inhibitors useful anticancer agents.
Regulatory Status:RUO - Research Use Only
HSP90β monoclonal antibody (K3701) Western blot
Western blot analysis: Lane 1: MW marker, Lane 2: HeL a, Lane 3: PC-12, Lane 4: CHO-K1, Lane 5: HSP90 Native Protein (Prod. No. ADI-SPP-770), Lane 6: HSP90 alpha Recombinant Protein (Prod. No. ADI-SPP-776) (negative control) , probed with HSP90 β mAb (K3701)
HSP90β monoclonal antibody (K3701) Flow Cytometry
Flow cytometric analysis human colon cancer Caco-2 cells analyzed by flow cytometry using isotype control antibody (left) or Hsp90 β mAb (K3701) (right).
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HSP90β monoclonal antibody (K3701) Western blot HSP90β monoclonal antibody (K3701) Flow Cytometry

Product Literature References

Indoleamine dioxygenase and tryptophan dioxygenase activities are regulated through GAPDH- and Hsp90-dependent control of their heme levels: P. Biswas, et al.; Free Radic. Biol. Med. 180, 179 (2022), Abstract;
S-glutathionylation of Hsp90 enhances its degradation and correlates with favorable prognosis of breast cancer: Y.Y. Shih, et al.; Redox Biol. 57, 102501 (2022), Abstract;
The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma: M. Heider, et al.; Mol. Cell 81, 1170 (2021), Abstract;

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