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TNF receptor 1 polyclonal antibody

ADI-CSA-815-D 50 µg 269.00 USD
ADI-CSA-815-F 200 µg 528.00 USD
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Product Details

Alternative Name:Tumor necrosis factor receptor 1, TNF-R1
Immunogen:Synthetic peptide corresponding to a portion of mouse TNF-R1. The sequence is completely conserved in rat and human.
UniProt ID:P25118
GenBank ID:X59238
Source:Purified from rabbit serum.
Species reactivity:Human, Mouse, Rat
Bovine, Dog, Drosophila, Hamster, Monkey, Porcine, Rabbit, Sheep, Xenopus, Yeast
Applications:IHC (PS), IP, WB
Recommended Dilutions/Conditions:Immunoprecipitation (12.5µg/ml)
Western Blot (1:1,000, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects a band of 55kDa by Western blot.
Purity Detail:Protein A affinity purified.
Formulation:Liquid. In PBS containing 50% glycerol and 0.09% sodium azide.
Shipping:Blue Ice
Long Term Storage:-20°C
Scientific Background:Tumor necrosis factor alpha (TNF-α), also known as cachectin, is a 17.5 kDa 157 amino acid member of the TNF superfamily of cytokines that is a potent lymphoid factor with effects on a wide range of target cells. Active TNFalpha is produced in both soluble and membrane-anchored trimers by macrophages, NK cells, and T- and B-lymphocytes. TNF exerts proinflammatory signals via binding and inducing trimerization of TNF-receptor1 (TNF-R1) expressed on most normal and transformed cells, or to TNF-receptor 2 (TNF-R2), expressed on endothelial and most immune cells. TNF signaling regulates hematopeiesis, differentation, endothelial cell activation, apoptosis, lipid metabolism, tumor progression, and immune suveillance, and dysregulation of TNF or its receptors is implicated in numerous disease states including cancer, osteoporosis, autoimmune disease, diabetes, and atherosclerosis.
Regulatory Status:RUO - Research Use Only
TNF receptor 1 polyclonal antibody Western blot
Western blot analysis of TNF-R1: Lane 1: MW marker, Lane 2: Hela (HS), Lane 3: Jurkat
TNF receptor 1 polyclonal antibody Immunohistochemistry
Immunohistochemistry analysis of human spleen tissue stained with TNF receptor 1 pAb at 10µg/ml.
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TNF receptor 1 polyclonal antibody Western blot TNF receptor 1 polyclonal antibody Immunohistochemistry

Product Literature References

Acute inflammation regulates neuroregeneration through the NF-κB pathway in olfactory epithelium: M. Chen, et al.; PNAS 114, 8089 (2017), Abstract; Full Text
Overexpression of TNF-α in mitochondrial diseases caused by mutations in mtDNA: evidence for signaling through its receptors on mitochondria: G. Vattemi, et al.; Free Radic. Biol. Med. 63, 108 (2013), Abstract;
Injury-induced neurogenesis: consideration of resident microglia as supportive of neural progenitor cells: C.A. McPherson, et al.; Neurotox. Res. 19, 341 (2011), Abstract; Full Text
Voluntary exercise protects hippocampal neurons from trimethyltin injury: possible role of interleukin-6 to modulate tumor necrosis factor receptor-mediated neurotoxicity: J.A. Funk, et al.; Brain Behav. Immun. 6, 1063 (2011), Abstract; Full Text
Tumor necrosis factor p55 and p75 receptors are involved in chemical-induced apoptosis of dentate granule neurons: G.J. Harry, et al.; J. Neurochem. 106, 281 (2008), Abstract;
Chronic physiological shear stress inhibits tumor necrosis factor-induced proinflammatory responses in rabbit aorta perfused ex vivo: H. Yamawaki, et al.; Circulation 108, 1619 (2003), Application(s): IP, WB using rabbit samples, Abstract;

General Literature References

TNF-R1 signaling: a beautiful pathway: G. Chen & D.V. Goeddel; Science 296, 1634 (2002), Abstract;
Induction of Jak/STAT signaling by activation of the type 1 TNF receptor: D. Guo, et al.; J. Immunol. 160, 2742 (1998), Abstract;
Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kinase upstream of MKK6 and p38: T. Yuasa, et al.; J. Biol. Chem. 273, 22681 (1998), Abstract;
A novel domain within the 55 kd TNF receptor signals cell death: L.A. Tartaglia, et al.; Cell 74, 845 (1993), Abstract;
Two human TNF receptors have similar extracellular, but distinct intracellular, domain sequences: Z. Dembic, et al.; Cytokine 2, 231 (1990), Abstract;

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