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CLIP monoclonal antibody (CerCLIP.1)

ADI-CSA-600-F 200 µg 501.00 USD
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Product Details

Immunogen:Synthetic peptide corresponding to a portion of human CLIP.
UniProt ID:P04233
GenBank ID:K01144
Source:Purified from mouse ascites.
Species reactivity:Human
Applications:Flow Cytometry, IP, WB
Recommended Dilutions/Conditions:Flow Cytometry (1:200)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Purity Detail:Protein G affinity purified.
Formulation:Liquid. In PBS containing 0.09% sodium azide.
Shipping:Blue Ice
Long Term Storage:-20°C
Scientific Background:CLIP (class II-associated invariant chain peptide) is an important peptide in the MHC-II antigen processing pathway, formed by the enzymatic cleavage of amino acids 81-104 from the invariant chain. During MHC-II synthesis in the ER and transport to endocytic vesicles, the antigen binding site of MHC-II is obstructed by the presence of the invariant chain. As the MHC-II complex moves through the Golgi, the invariant chain is degraded, leaving the CLIP fragment in the MHC-II peptide binding groove. CLIP is eventually displaced by the loading of antigenic peptides, followed by presentation on the APC cell surface to CD4+ T-cells.
Regulatory Status:RUO - Research Use Only

Product Literature References

HLA-DM interactions with intermediates in HLA-DR maturation and a role for HLA-DM in stabilizing empty HLA-DR molecules: P. Cresswell, et al. ; J. Exp. Med. 184, 2153 (1996), Application(s): Other using human samples, Abstract;
HLA-DM induces CLIP dissociation from MHC class II alpha beta dimers and facilitates peptide loading: P. Cresswell, et al. ; Cell 82, 155 (1995), Application(s): Other using human samples, Abstract;
Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells: P. Cresswell, et al. ; Immunity 1, 595 (1994), Application(s): IP, Flow using human samples, Abstract;

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