Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Mcl-1 polyclonal antibody

ADI-AAP-240-D 50 µg 283.00 USD
ADI-AAP-240-F 200 µg 501.00 USD
Do you need bulk/larger quantities?

Product Details

Alternative Name:Bcl-2-like protein 3
Immunogen:Synthetic peptide corresponding to a portion of human Mcl-1.
UniProt ID:Q07820
GenBank ID:L08246
Source:Purified from rabbit serum.
Species reactivity:Human
Dog, Guinea pig, Monkey, Porcine, Rabbit
Applications:IF, IHC (PS), WB
Recommended Dilutions/Conditions:Immunohistochemistry (paraffin sections, 1:50)
Western Blot (1:500-1:1,000, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects a band of ~42/43kDa by Western blot.
Purity Detail:Peptide affinity purified.
Formulation:Liquid. In PBS containing 0.09% sodium azide.
Handling:Avoid freeze/thaw cycles.
Shipping:Blue Ice
Long Term Storage:-20°C
Scientific Background:Mcl-1 is a member of the Bcl-2 family that possesses anti-apoptotic activity. Mcl-1 is an immediate-early gene activated by the GMCSF as well as IL-3 signaling pathways and plays an important role in the viability response of these cytokines. Similar to all Bcl-2 family members, Mcl-1 contains BH1, BH2, and BH3 domains; however, unlike other members of this family, Mcl-1 has an extended N-terminal domain rich in PEST sequences, which probably accounts for the short half-life of this protein.
Regulatory Status:RUO - Research Use Only
Mcl-1 polyclonal antibody Western blot
Western blot analysis of Mcl-1, pAb: Lane 1: MW marker, Lane 2: HeLa, Lane 3: 3T3, Lane 4: PC-12, Lane 5: MDCK, Lane 6: RK-13.
Mcl-1 polyclonal antibody Immunofluorescence
Immunofluorescent analysis (confocal) staining of HeLa cells using Mcl-1 pAb (green); nuclei are stained in blue pseudocolor using DRAQ5.
Mcl-1 polyclonal antibody Immunohistochemistry
Immunohistochemistry analysis of human breast cancer tissue with Mcl-1 pAb.
Please mouse over
Mcl-1 polyclonal antibody Western blot Mcl-1 polyclonal antibody Immunofluorescence Mcl-1 polyclonal antibody Immunohistochemistry

Product Literature References

A broad-based approach to differentiate CIN from its mimics: The utility of in situ hybridization and immunohistochemistry: G. Nuovo; Ann. Diagn. Pathol. 46, 151515 (2020), Application(s): IHC on cervical biopsies., Abstract;
Combination of fenretinide and ABT-263 induces apoptosis through NOXA for head and neck squamous cell carcinoma treatment: E.L. Britt, et al.; PLoS One 14, e0219398 (2019), Abstract; Full Text
Cyclin-dependent kinase-1 (Cdk1)/cyclin B1 dictates cell fate after mitotic arrest via phosphoregulation of antiapoptotic Bcl-2 proteins: N. Sakurinkar, et al.; J. Biol. Chem. 287, 39193 (2018), Abstract; Full Text
Increased expression of importin-β, exportin-5 and nuclear transportable proteins in Alzheimer's disease aids anatomic pathologists in its diagnosis: G. Nuovo, et al.; Ann. Diag. Pathol. 32, 10 (2018), Application(s): Immunohistochemistry on human brain FFPE tissue, Abstract;
Intracellular Desmoglein-2 cleavage sensitizes epithelial cells to apoptosis in response to pro-inflammatory cytokines: M. Yulis, et al.; Cell Death Dis. 9, 389 (2018), Abstract; Full Text
Critical role of mitochondria-mediated apoptosis for JNJ-26481585-induced antitumor activity in rhabdomyosarcoma: U. Heinicke, et al.; Oncogene 35, 3729 (2016), Application(s): Western Blot, Abstract;
Low expression of pro-apoptotic Bcl-2 family proteins sets the apoptotic threshold in Waldenström macroglobulinemia: B.T. Gaudette, et al.; Oncogene 35, 479 (2016), Application(s): Western Blot, Abstract;
Identification of synthetic lethality of PLK1 inhibition and microtubule-destabilizing drugs: M. Hugle, et al.; Cell Death Differ. 22, 1946 (2015), Application(s): Western Blot, Abstract;

Related Products

HeLa (heat shocked) , (cell lysate) 

Human, WB | Print as PDF
ADI-LYC-HL101-F 200 µg 141.00 USD
Do you need bulk/larger quantities?

Product Toolbox


Certificate of Analysis


By target:
By biological activity:
Mcl Polyclonal antibody
By catalog section:


Technical Service
Customer Service

Related Literature

Download as PDF

All new literature pieces