| ENZ-ABS332-0100 | 100 µg | 580.00 USD |  |
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| Alternative Name: | vWF |
| Clone: | VWF/1859R |
| Host: | Rabbit |
| Isotype: | IgGκ |
| Immunogen: | Recombinant human von Willebrand factor (aa 1815-1939). |
| UniProt ID: | P04275 |
| Species reactivity: | Human |
| Applications: | IHC (PS), WB |
| Recommended Dilutions/Conditions: | Immunohistochemistry (formalin-fixed paraffin sections) (1-2 µg/mL) for 30 minutes at RT Western blot (1-2 µg/mL) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Application Notes: | This antibody helps to establish the endothelial nature of some lesions of disputed histogenesis, e.g. Kaposi's sarcoma and cardiac myxoma. It is widely used for differentiating vascular lesions from those of other tissue differentiation within a panel of other vascular markers although not all tumors of endothelial differentiation contain this antigen. |
| Purity Detail: | Protein A affinity purified. |
| Formulation: | Liquid. In 1X PBS containing 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide. |
| Shipping: | Blue Ice |
| Long Term Storage: | +4°C |
| Scientific Background: | von Willebrand Factor (vWF) is a multimeric glycoprotein that is found in endothelial cells, plasma and platelets. It acts as a carrier protein for Factor VIII and promotes platelet adhesion and aggregation. vWF undergoes a variety of posttranslational modifications that influence the affinity and availability for Factor VIII, including cleavage of the propeptide and formation of N-terminal disulfide bonds. |
| Regulatory Status: | RUO - Research Use Only |
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