| ENZ-ABS307-0100 | 100 µg | 640.00 USD |  |
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| Alternative Name: | S100 β |
| Clone: | S100B/1706R |
| Host: | Rabbit |
| Isotype: | IgGκ |
| Immunogen: | Recombinant full length human S100B. |
| UniProt ID: | P04271 |
| Species reactivity: | Human, Mouse, Rat |
| Specificity: | This antibody is specific against an epitope located on the β-chain (i.e. in S-100A and S-100B) but not on the alpha-chain of S-100 (i.e. in S-100A and S100A0). |
| Applications: | Flow Cytometry, IF, IHC (PS), WB |
| Recommended Dilutions/Conditions: | Flow Cytometry (0.5-1 µg/106 cells in 0.1 mL) Immunofluorescence (1-2 µg/mL) Western blot (0.5-1 µg/mL) Immunohistochemistry (formalin-fixed paraffin sections) (0.25-0.5 µg/mL for 30 min at RT) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Application Notes: | This antibody can be used to localize S-100A and S-100B in various tissue sections. |
| Purity Detail: | Protein A affinity purified. |
| Formulation: | Liquid. In 1X PBS containing 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide. |
| Shipping: | Blue Ice |
| Long Term Storage: | +4°C |
| Scientific Background: | S100 belongs to the family of calcium binding proteins. S100A and S100B proteins are two members of the S100 family. S100A is composed of an α and a β chain whereas S100B is composed of two β chains. S-100 protein has been found in normal melanocytes, Langerhans cells, histiocytes, chondrocytes, lipocytes, skeletal and cardiac muscle, Schwann cells, epithelial and myoepithelial cells of the breast, salivary and sweat glands, as well as in glial cells. Neoplasms derived from these cells also express S-100 protein, albeit non-uniformly. A large number of well-differentiated tumors of the salivary gland, adipose and cartilaginous tissue, and Schwann cell-derived tumors express S-100 protein. Almost all malignant melanomas and cases of histiocytosis X are positive for S-100 protein. |
| Regulatory Status: | RUO - Research Use Only |
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