Anti-tumor agent that disrupts the canonical Wnt/β-catenin pathway via blockage of the protein-protein interaction between β-catenin and TCF.
Product Details
| Alternative Name: | 2-Phenoxybenzoic acid [(5-methyl-2-furanyl)methylene]hydrazide |
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| Formula: | C19H16N2O3 |
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| MW: | 320.3 |
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| CAS: | 113906-27-7 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | Off-white solid. |
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| Solubility: | Soluble in DMSO (25 mg/ml) and in 100% ethanol (8 mg/ml). |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 6 months after receipt when stored at -20°C. |
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| Handling: | Solutions can be stored at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Wnt/β-Catenin Protects Lymphocytes from HIV-Mediated Apoptosis via Induction of Bcl-xL: Y.A. Albalawi, et al.; Viruses
14, 1469 (2022),
Abstract;
Inhibition of protein-protein interactions: The discovery of druglike ß-catenin inhibitors by combining virtual and biophysical screening: J.-Y. Trosset, et al.; Proteins
64, 60 (2006),
Abstract;
Mining the Wnt pathway for cancer therapeutics: N. Barker & H. Clevers; Nat. Rev. Drug Discov.
5, 997 (2006),
Abstract;
