This unique SH2 domain ligand is derived from the sequence flanking Tyr751 of the PDGF receptor. It inhibits the PI 3-kinase p85 C-terminal SH2 domain (IC50=14.2 µM). It contains the nonhydrolyzable phosphotyrosine mimetic L-O-(2-malonyl)tyrosine (OMT) and is provided as the trimethyl ester for greater cell permeability.
Product Details
| Sequence: | Ac-Asp-Tyr(2-malonyl)-Val-Pro-Met-Leu-NH2 trimethyl ester |
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| MW: | 922.1 |
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| Formulation: | Lyophilized. |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Yellow solid. |
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| Solubility: | Soluble in DMSO (0.5 mg/ml) or ethanol (0.3 mg/ml). |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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