Propranolol blocks PLD derived DAG formation by inhibiting phosphatidate phosphohydrolase (IC50=70 µM). It is a useful tool to discriminate between PLC or PLD mediated DAG production. It is also a β-adrenergic receptor blocking agent.
Product Details
| Formula: | C16H21NO2 . HCl |
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| MW: | 295.8 |
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| CAS: | 318-98-9 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Determined by 1H-NMR and LC-MS. |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Regulation of phospholipase D in HL-60 granulocytes. Activation by phorbol esters, diglyceride, and calcium ionophore via protein kinase- independent mechanisms: M. M. Billah, et al.; J. Biol. Chem.
264, 9069 (1989),
Abstract;
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The biological properties of the optical isomers of propranolol and their effects on cardiac arrhythmias: A. M. Barrett, et al.; Br. J. Pharmacol.
34, 43 (1968),
Abstract;
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