In the presence of ethanol, phospholipase D converts phosphatidylcholine to phosphatidylethanol. This conversion is the basis of a sensitive and selective assay for PLD activity in intact cells. Phosphatidylethanol is a useful chromatographic standard for this assay.
Product Details
| Alternative Name: | 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanol, PEth-16:0/18:1 |
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| Formula: | C39H75O8P |
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| MW: | 703 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Viscous oil or waxy solid. |
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| Solubility: | Soluble in chloroform. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Protect from oxygen. Store under inert gas. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Phosphatidylethanol biosynthesis in ethanol-exposed NG108-15 neuroblastoma X glioma hybrid cells. Evidence for activation of a phospholipase D phosphatidyl transferase activity by protein kinase C: M. Liscovitch; J. Biol. Chem.
264, 1450 (1989),
Abstract;
Phospholipase D catalyzes phospholipid metabolism in chemotactic peptide-stimulated HL-60 granulocytes: J.-K. Pai et al.; J. Biol. Chem.
263, 12472 (1988),
Abstract;
Formation of phosphatidylethanol in rat brain by phospholipase D
: L. Gustavsson & C. Alling; Biochem. Biophys. Res. Commun.
142, 958 (1987),
Abstract;
Phosphatidylethanol formation via transphosphatidylation by rat brain synaptosomal phospholipase D: M. Kobayashi & J.N. Kanfer; J. Neurochem.
48, 1597 (1987),
Abstract;
